ID  Q866F4;
PN  Adenylate cyclase type 10;
GN  ADCY10;
OS  9986;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000250|UniProtKB:Q96PN6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96PN6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96PN6}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q96PN6}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PN6}. Nucleus {ECO:0000250|UniProtKB:Q96PN6}. Cell projection, cilium {ECO:0000250|UniProtKB:Q96PN6}. Cytoplasm {ECO:0000250|UniProtKB:Q96PN6}. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane- associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {ECO:0000250|UniProtKB:Q96PN6}.
DR  UNIPROT: Q866F4;
DR  Pfam: PF00211;
DR  PROSITE: PS50125;
DE  Function: Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity). {ECO:0000250|UniProtKB:Q8C0T9, ECO:0000250|UniProtKB:Q96PN6}.
DE  Reference Proteome: Yes;
GO  GO:0005929;
GO  GO:0005856;
GO  GO:0005576;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0004016;
GO  GO:0005524;
GO  GO:0071890;
GO  GO:0000287;
GO  GO:0006171;
GO  GO:0071241;
GO  GO:0003351;
GO  GO:0035556;
GO  GO:0007283;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q96PN6};
SQ  MNTRKEELQDRAIVRIAAHLPDLIVYGDFSPQRPSVDYFDGVLMFVDISGFTAMTEKFSTAMYMDRGAEQLVEILNYYIS
SQ  AIVEKVLIFGGDILKFAGDALLALWKVERKQLKNIITVVIKCSLEIHGLFGTQESEEGLDIRVKIGLAAGHISMLVFGDE
SQ  TRNHFLVIGQAVDDVRLAQNMARMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVNFLKPPPSFNFDEFFNKCMTFMDYY
SQ  PSGDHKNLLRLACMLESDPDLELSLQKYVMESILKQIDDKQLRGYLSELRPVTIVFVNLMFQDQNKAEVIGSAIQDACVH
SQ  ISSVLKVFRGQINKVFMFDKGCSFLCVFGFPGEKAPDEVTHALESAVDIFDFCSQVHKIHTVSIGVASGIVFCGIVGHTV
SQ  RHEYTVIGQKVNIAARMMMYYPGIVTCDSVTYNGSNLPPYFFKELPKKLMKGVGDSGPVYQCLGLNEKVMFGMAYLTCNR
SQ  NEGYPLLGRDKEIKYFMCTMKEFLMSNCSRVLMYEGLSGFGKSRILMEIEYLAQGENHRTIAIALTKVSFHQNFYTIQIL
SQ  MANVLGLDTCKHYKERQTNLQNKVKTLLDEKFHCLLNDIFHVQFPISREISKMSTFRKQKQLEALFMKILEQTVKEERII
SQ  FIIDEAQFVDYASWIFMEKLIRTVPIFIIMSLSPFTEIPCAAASAIMKNRNTTYVTLGAVQPNDIRNKVCLDLNVSSIPK
SQ  ELDLYLVEGSCGIPFYCEELVKNLDHHRVLVFQQMETEEKTKVTWNNLFKNFIKPTEEFKMSGLGNEEGTEEICKLASGV
SQ  RLKNLSPPASLKEISLVQLDSMSLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKALATLVESNIFDCFRDGKDLR
SQ  LALKQNAASFEVHNRSLSLQPTEGIAHGEEEELRELESEVIECHIIRFCKPMMQKTAYELWLKDQKKAMHLKCARFLEEN
SQ  AHRCDHCRSGDFIPYHHFTVDIRLNTLDMDTIKKMATSHGFETEEEIKISRAGIPKNSELFSENLSPEEIGERILGFFDV
SQ  ILTKMKTSKEDIIPLESCQCEEILEIVILPLAQHFLALGENNKALYYFLEITSAYLTLGDNYMAYMYLNEGERLLKTLKK
SQ  EKSWSQTFESATFYSLKGQVCFNMGQMVLAKKMLRKALKLLNRIFPYNLISLFLHTHMEKNRHFHYVTQQAQESSPPGKK
SQ  RLAHLYQQTACFSLLWQIYSLNYFFHHKYYGHLAAMMELNTALETQNDFQIIKAYLDYAMYHHLAGYQGVWFKYEVKAME
SQ  QIFNLPLKGEGIEIVAYVAGKLSYIKLMMGYLDLAIELGARAHKMWALLQNPNQHYVVLCRLSKSLFLKNRYKHLIQMLR
SQ  RLWDLSVAEGHIISKAFFYLVCLDIMLYSGFVYRTFEECLEFIIQNEDNRILKFQSGLLLGLYSSIAIWYGRLQEWDNFY
SQ  VFSNRAKTLVSRRTPTILYYDGVSRYMEGQVLQLQKQIEEQSETAQDSGVELLKSLESLVAQNTTGPVFYPRLYHLMAYI
SQ  CILMGDGQNCDLFLNTALKLSEIQGNVLEKCWLNMSKEWWYSNCTLTEDQWLHTILSLPAWEKIVSGKVNIHDVQKNKFL
SQ  MRVNILDNPF
//