ID  Q86HW7;
PN  Nuclear transport factor 2;
GN  nutf2;
OS  44689;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61970}. Nucleus outer membrane {ECO:0000250|UniProtKB:P61972}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P61972}. Nucleus inner membrane {ECO:0000250|UniProtKB:P61972}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P61970}. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000250|UniProtKB:P61970}.
DR  UNIPROT: Q86HW7;
DR  UNIPROT: Q551K9;
DR  Pfam: PF02136;
DR  PROSITE: PS50177;
DE  Function: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000250|UniProtKB:P61970}.
DE  Reference Proteome: Yes;
DE  Interaction: O76329; IntAct: EBI-922911; Score: 0.40
GO  GO:0005829;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0005640;
GO  GO:0044613;
GO  GO:0005654;
GO  GO:0031267;
GO  GO:0017056;
GO  GO:0051028;
GO  GO:0006913;
GO  GO:0006606;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MQSVDPQVVGVGKQFVEHYYGIFDSNRAGLTQIYQQQTTLTWEGKFLSGADAIVKHIVELPFQQTNRKINSIDCQQTYQP
SQ  GIMITVTGTLIIDGEAKNQLKFVQVFNLASNNGSFLLINDFFRLVLD
//