ID  Q86T96;
PN  E3 ubiquitin-protein ligase RNF180;
GN  RNF180;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope {ECO:0000250|UniProtKB:Q3U827}.
DR  UNIPROT: Q86T96;
DR  UNIPROT: Q0JSU3;
DR  UNIPROT: Q495A8;
DR  UNIPROT: Q8NBD1;
DR  Pfam: PF19332;
DR  PROSITE: PS00518;
DR  PROSITE: PS50089;
DR  OMIM: 616015;
DR  DisGeNET: 285671;
DE  Function: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {ECO:0000250|UniProtKB:Q3U827}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0031227;
GO  GO:0005635;
GO  GO:0046872;
GO  GO:0031624;
GO  GO:0061630;
GO  GO:0030534;
GO  GO:0042415;
GO  GO:0032436;
GO  GO:0031398;
GO  GO:0000209;
GO  GO:0050790;
GO  GO:0042428;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYLENQVIKDKDDSVDAQNICHVWHMNVEALPEWISCLIQKAQW
SQ  TVGKLNCPFCGARLGGFNFVSTPKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSHPRVQSGCDKEALLTGGGSEN
SQ  RNHRLLNMARNNNDPGRLTEALCLEVRPTYFEMKNEKLLSKASEPKYQLFVPQLVTGRCATRAFHRKSHSLDLNISEKLT
SQ  LLPTLYEIHSKTTAYSRLNETQPIDLSGLPLQSSKNSYSFQNPSSFDPSMLLQRFSVAPHETQTQRGGEFQCGLEAASVY
SQ  SDHTNTNNLTFLMDLPSAGRSMPEASDQEEHLSPLDFLHSANFSLGSINQRLNKRERSKLKNLRRKQRRRERWLQKQGKY
SQ  SGVGLLDHMTLNNEMSTDEDNEYAEEKDSYICAVCLDVYFNPYMCYPCHHIFCEPCLRTLAKDNPSSTPCPLCRTIISRV
SQ  FFQTELNNATKTFFTKEYLKIKQSFQKSNSAKWPLPSCRKAFHLFGGFRRHAAPVTRRQFPHGAHRMDYLHFEDDSRGWW
SQ  FDMDMVIIYIYSVNWVIGFIVFCFLCYFFFPF
//