ID  Q86UE8;
PN  Serine/threonine-protein kinase tousled-like 2;
GN  TLK2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
DR  UNIPROT: Q86UE8;
DR  UNIPROT: D3DU07;
DR  UNIPROT: Q9UKI7;
DR  UNIPROT: Q9Y4F7;
DR  PDB: 5O0Y;
DR  PDB: 7LO0;
DR  Pfam: PF00069;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DR  OMIM: 608439;
DR  OMIM: 618050;
DR  DisGeNET: 11011;
DE  Function: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:9427565}.
DE  Disease: Intellectual developmental disorder, autosomal dominant 57 (MRD57) [MIM:618050]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD57 is characterized by delayed psychomotor development apparent in infancy or early childhood, and a variety of behavioral abnormalities. Affected individuals may have severe gastro-intestinal problems, and facial dysmorphism. {ECO:0000269|PubMed:27479843, ECO:0000269|PubMed:29861108}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: Q0D2I5; IntAct: EBI-11911984; Score: 0.00
DE  Interaction: Q9NVP2; IntAct: EBI-25476220; Score: 0.56
DE  Interaction: Q15306; IntAct: EBI-6115566; Score: 0.50
DE  Interaction: Q92985; IntAct: EBI-6115673; Score: 0.50
DE  Interaction: Q15418; IntAct: EBI-6256547; Score: 0.35
DE  Interaction: E9Q4K7; IntAct: EBI-11042417; Score: 0.35
DE  Interaction: P63167; IntAct: EBI-12449761; Score: 0.64
DE  Interaction: P56726; IntAct: EBI-11127526; Score: 0.35
DE  Interaction: Q9Y294; IntAct: EBI-11137466; Score: 0.53
DE  Interaction: Q96FJ2; IntAct: EBI-12449804; Score: 0.64
DE  Interaction: P26367; IntAct: EBI-24282100; Score: 0.56
DE  Interaction: Q86UE8; IntAct: EBI-24307235; Score: 0.56
DE  Interaction: Q8NHQ1; IntAct: EBI-24339490; Score: 0.56
DE  Interaction: Q96IK5; IntAct: EBI-24367628; Score: 0.56
DE  Interaction: Q96NE9; IntAct: EBI-23847597; Score: 0.56
DE  Interaction: Q02548; IntAct: EBI-24416001; Score: 0.56
DE  Interaction: Q9NPF5; IntAct: EBI-25206676; Score: 0.56
DE  Interaction: Q7KZS0; IntAct: EBI-25226009; Score: 0.56
DE  Interaction: Q53SF7; IntAct: EBI-11916124; Score: 0.00
DE  Interaction: Q8IY63; IntAct: EBI-11921650; Score: 0.00
DE  Interaction: Q9BWV3; IntAct: EBI-11930524; Score: 0.00
DE  Interaction: Q9UN30; IntAct: EBI-11939262; Score: 0.00
DE  Interaction: Q9UPM6; IntAct: EBI-21621887; Score: 0.35
DE  Interaction: Q5VX52; IntAct: EBI-21635815; Score: 0.35
DE  Interaction: Q8N140; IntAct: EBI-21773860; Score: 0.35
DE  Interaction: Q9UHA7; IntAct: EBI-21786920; Score: 0.35
DE  Interaction: O75679; IntAct: EBI-21798659; Score: 0.35
DE  Interaction: Q9Y6J0; IntAct: EBI-21877366; Score: 0.35
DE  Interaction: Q9UKI8; IntAct: EBI-21877366; Score: 0.35
DE  Interaction: P62979; IntAct: EBI-21877366; Score: 0.35
DE  Interaction: P27361; IntAct: EBI-28934804; Score: 0.35
DE  Interaction: Q96IU4; IntAct: EBI-28942113; Score: 0.35
DE  Interaction: Q96FZ7; IntAct: EBI-28942113; Score: 0.35
DE  Interaction: Q5T3J3; IntAct: EBI-28942113; Score: 0.35
DE  Interaction: P49458; IntAct: EBI-28942113; Score: 0.35
DE  Interaction: P25205; IntAct: EBI-28942113; Score: 0.35
DE  Interaction: P12004; IntAct: EBI-28942113; Score: 0.35
DE  Interaction: Q13257; IntAct: EBI-30825948; Score: 0.44
GO  GO:0005882;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0042802;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0007049;
GO  GO:0006974;
GO  GO:0071480;
GO  GO:0006325;
GO  GO:0007059;
GO  GO:0035556;
GO  GO:0051179;
GO  GO:0010507;
GO  GO:0032435;
GO  GO:0018105;
GO  GO:0006468;
GO  GO:1902275;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPR
SQ  GHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLD
SQ  TEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLR
SQ  ANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQN
SQ  LIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLA
SQ  EYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAF
SQ  DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHK
SQ  LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGT
SQ  YWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRR
SQ  CLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
//