ID  Q86VF5;
PN  2-acylglycerol O-acyltransferase 3;
GN  MOGAT3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27184406}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27184406}.
DR  UNIPROT: Q86VF5;
DR  UNIPROT: Q496A6;
DR  UNIPROT: Q496A7;
DR  UNIPROT: Q496A8;
DR  UNIPROT: Q9UDW7;
DR  Pfam: PF03982;
DR  OMIM: 610184;
DR  DisGeNET: 346606;
DE  Function: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000269|PubMed:12618427, ECO:0000269|PubMed:27184406, ECO:0000269|PubMed:28420705}.
DE  Reference Proteome: Yes;
DE  Interaction: P07339; IntAct: EBI-25840151; Score: 0.56
DE  Interaction: G5E9A7; IntAct: EBI-25843901; Score: 0.56
DE  Interaction: P28799; IntAct: EBI-25862183; Score: 0.56
DE  Interaction: O76024; IntAct: EBI-25900416; Score: 0.56
DE  Interaction: Q7Z699; IntAct: EBI-25933765; Score: 0.56
GO  GO:0005789;
GO  GO:0016021;
GO  GO:1990578;
GO  GO:0003846;
GO  GO:0004144;
GO  GO:0006071;
GO  GO:0006629;
GO  GO:0006640;
GO  GO:0019432;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGVATTLQPPTTSKTLQKQHLEAVGAYQYVLTFLFMGPFFSLLVFVLLFTSLWPFSVFYLVWLYVDWDTPNQGGRRSEWI
SQ  RNRAIWRQLRDYYPVKLVKTAELPPDRNYVLGAHPHGIMCTGFLCNFSTESNGFSQLFPGLRPWLAVLAGLFYLPVYRDY
SQ  IMSFGLCPVSRQSLDFILSQPQLGQAVVIMVGGAHEALYSVPGEHCLTLQKRKGFVRLALRHGASLVPVYSFGENDIFRL
SQ  KAFATGSWQHWCQLTFKKLMGFSPCIFWGRGLFSATSWGLLPFAVPITTVVGRPIPVPQRLHPTEEEVNHYHALYMTALE
SQ  QLFEEHKESCGVPASTCLTFI
//