ID  Q86YW0;
PN  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1;
GN  PLCZ1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
DR  UNIPROT: Q86YW0;
DR  UNIPROT: Q08AQ7;
DR  UNIPROT: Q96J70;
DR  Pfam: PF00168;
DR  Pfam: PF09279;
DR  Pfam: PF00388;
DR  Pfam: PF00387;
DR  PROSITE: PS50004;
DR  PROSITE: PS50222;
DR  PROSITE: PS50007;
DR  PROSITE: PS50008;
DR  OMIM: 608075;
DR  OMIM: 617214;
DR  DisGeNET: 89869;
DE  Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:12416999, ECO:0000269|PubMed:14697805, ECO:0000269|PubMed:15579586, ECO:0000269|PubMed:26721930, ECO:0000305}.
DE  Disease: Spermatogenic failure 17 (SPGF17) [MIM:617214]: An autosomal recessive infertility disorder due to failure of oocyte activation and fertilization by sperm that otherwise exhibits normal morphology. {ECO:0000269|PubMed:26721930}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: Q15828; IntAct: EBI-21829478; Score: 0.35
DE  Interaction: Q8IW75; IntAct: EBI-21829478; Score: 0.35
DE  Interaction: Q16610; IntAct: EBI-21829478; Score: 0.35
DE  Interaction: P49862; IntAct: EBI-21829478; Score: 0.35
DE  Interaction: P42357; IntAct: EBI-21829478; Score: 0.35
DE  Interaction: P04279; IntAct: EBI-21829478; Score: 0.35
DE  Interaction: P06748; IntAct: EBI-20903472; Score: 0.40
DE  Interaction: P68032; IntAct: EBI-20905688; Score: 0.40
DE  Interaction: P14314; IntAct: EBI-20907800; Score: 0.40
GO  GO:0005829;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0045120;
GO  GO:0061827;
GO  GO:0005509;
GO  GO:0004435;
GO  GO:0032266;
GO  GO:0005546;
GO  GO:0010314;
GO  GO:0006816;
GO  GO:0007343;
GO  GO:0016042;
GO  GO:0048015;
GO  GO:0007204;
GO  GO:0060470;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTY
SQ  SENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHP
SQ  LNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTS
SQ  DYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQ
SQ  DKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTR
SQ  KFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGM
SQ  PITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVEGQG
SQ  LIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYVWYVR
//