ID  Q89709;
PN  cap-snatching endonuclease;
GN  L;
OS  1980491;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
DR  UNIPROT: Q89709;
DR  UNIPROT: A0A059WB91;
DR  Pfam: PF04196;
DR  Pfam: PF12426;
DR  PROSITE: PS50525;
DE  Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap- snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity). {ECO:0000250|UniProtKB:Q9E005}.
DE  Reference Proteome: No;
GO  GO:0044220;
GO  GO:0004519;
GO  GO:0046872;
GO  GO:0000166;
GO  GO:0003968;
GO  GO:0075526;
GO  GO:0006351;
GO  GO:0039694;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEKYREIHQRVKEIPPGGASALECLDLLDRLYAVRHDVVDQMIKHDWSDNKDMERPIGQVLLMAGVPNDVIQGMEKKVIP
SQ  TSPSGQILKSFFRMTPDNYKITGALIEFIEVTVTADVAKGIREKKLKYESGLQFVESLLSQEHKKGNINQAYKITFDVVA
SQ  VKTDGSNISTQWPSRRNDGVVQHMRLVQADINYVREHLIKPDERASLEAMFNLKFHVGGPKLRYFNIPDYKPQSLCQPEI
SQ  TNLIQYCKHWLTEDHDFVFKEVTGNNVMNSFENNESVYMSRYRESRKPRNFLLIQGSIQGPYLPSTISSDQCDTRIGCLE
SQ  VLKVHPETPVQAIAVDMAYKYMELNRDEIINYYNPRVHFQATQSVKEPGTFKLGLSQLNPMSKSILDQVGKHKSEKGLFG
SQ  EPLESINISSQIQQNECSRIIESILSNLEINVGEVTMSLANPRKTTGVDELLGKFYENELSKYLISILRKTAAWHIGHLI
SQ  RDITESLIAHAGLKRSKYWSIHAYDHGGVILFILPSKSLEVVGSYIRYFTVFKDGIGLIDEENLDSKVDIDGVQWCFSKV
SQ  MSIDLNRLLALNIAFEKALLATATWFQYYTEDQGHFPLQHALRSVFSFHFLLCVSQKMKICAIFDNLRYLIPAVTSLYSG
SQ  YELLIEKFFERPFKSALEVYLYNIIKALLISLAQNNKVRFYSKVRLLGLTVDHSTVGASGVYPSLMSRVVYKHYRSLISE
SQ  ATTCFFLFEKGLHGNLNEEAKIHLETVEWARKFEAKERKYGDILMREGYTIDAIRVGDVQVEQQLFCQEVVELSAEELNK
SQ  YLQAKSQVLSSNIMNKHWDKPYFSQTRNISLKGMSGALQEDGHLAASVTLIEAIRFLNRSQTNPNVIDMYEQTKQHKAQA
SQ  RIVRKYQRTEADRGFFITTLPTRVRLEIIEDYYDAIARVVPEEYISYGGDKKILNIQTALEKALRWASGSSEVITSTGNV
SQ  IKFKRRLMYVSADATKWSPGDNSAKFKRFTQALYDGLSDEKLKCCVVDALRHVYETEFFMSRKLHRYIDSMDEHSEAVQD
SQ  FLDFFKGGVSATVKGNWLQGNLNKCSSLFGAAVSLLFRRIWAELFPELECFFEFAHHSDDALFIYGYLEPEDDGTDWFLY
SQ  VSQQIQAGNYHWHAVNQEMWKSMFNLHEHLLLMGSIKVSPKKTTVSPTNAEFLSTFFEGCAVSIPFIKILLGSLSDLPGL
SQ  GFFDDLAAAQSRCVKAMDLGASPQLAQLAVVICTSKVERLYGTADGMVNSPVAFLKVTKAHVPIPLGGDGSMSIMELATA
SQ  GIGMADKNILKQAFYSYKHTRRDGDRYVLGLFKFLMSLSEDVFQHDRLGEFSFVGKVQWKVFTPKNEFEFFDQFSQSYLK
SQ  SWTNQHPVYDYIIPRGRDNLLVYLVRKLNDPSIVTAMTMQSPLQLRFRMQAKQHMKVCKLEGEWVTFREVLAAADSFATK
SQ  YNPTEKDLDLFNTLVSCTFSKEYAWKDFLNEVRCEVVPTKHVHRSKIARTFTVREKDQAIQNPITAVIGYKYASTVDEIS
SQ  DVLDSSFFPDSLSADLQVMKEGVYRELGLDIGLPEVLKRIAPLLYKAGRSRVVIVEGNVEGTAESICSYWLRSMSLVKTI
SQ  KVRPKKEVLRAVSLYSTKENIGLQDDVAATRLCIEVWRWCKANDQNVNDWLNALYFEKQTLMDWVERFRRKGVVPIDPEI
SQ  QCIALLLYDVLGYKSVLQMQANRRAYSGKQYDAYCVQTYNEETRLYEGDLRVTFNFGLDCARLEIFWDKKEYILETSITQ
SQ  RHVLKLMMEEVTQELLRCGMRFKTEQVSHTRSLVLFKTESGFEWGKPNVPCIVFKHCALRTGLRTKQAINKEFMINVQAD
SQ  GFRAIAQMDMESPRFLLAHAYHTLRDVRYQAVQAVGNVWFQTAQHKLFINPIISSGLLENFMKGLPAAIPPAAYSLIMNK
SQ  AKISVDLFMFNELLALVNPRNVLNLDGIEETSEGYSTVTSISSRQWSEEVSLMADDDIDDEEEFTIALDDIDFEQINLDE
SQ  DIQHFLQDESAYTGDLTIQTEEVEVKRIRGVTRVLEPVKLIKSWVSKGLAIDKVYNPIGIVLMARYMSKNYDFSKIPLAL
SQ  LNPYDLTEFESVVKGWGETVNDRFLEVDNDAQRLVREKNILPEDILPDSLFSFRHVDVLLKRLFPHDPVSSFY
//