ID  Q8BFV2;
PN  PCI domain-containing protein 2;
GN  Pcid2;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:Q5JVF3}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q5JVF3}.
DR  UNIPROT: Q8BFV2;
DR  UNIPROT: Q147Z6;
DR  UNIPROT: Q8C951;
DR  Pfam: PF01399;
DR  PROSITE: PS50250;
DE  Function: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (PubMed:20870947). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability (By similarity). Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (PubMed:29138493). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (PubMed:29138493). {ECO:0000250|UniProtKB:Q5JVF3, ECO:0000269|PubMed:20870947, ECO:0000269|PubMed:29138493}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9EPK7; IntAct: EBI-17171503; Score: 0.35
GO  GO:0005737;
GO  GO:0044615;
GO  GO:0005634;
GO  GO:0070390;
GO  GO:0003690;
GO  GO:0003723;
GO  GO:0043066;
GO  GO:2000117;
GO  GO:1905457;
GO  GO:0016973;
GO  GO:0045579;
GO  GO:0045893;
GO  GO:0090267;
GO  GO:0000973;
GO  GO:1900049;
GO  GO:0043488;
GO  GO:0048536;
GO  GO:0006368;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAHITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEA
SQ  YKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRIFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGI
SQ  EDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGRKAMFDSDFKQAEEYLSFAFEHC
SQ  HRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHLMQFSEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKII
SQ  TYRNLFKKVYLLLKTHQLSLDAFLVALKFMHVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSTVC
//