ID  Q8BVF2;
PN  Phosducin-like protein 3;
GN  Pdcl3;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:27496612}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9H2J4}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H2J4}.
DR  UNIPROT: Q8BVF2;
DR  UNIPROT: Q3TH06;
DR  UNIPROT: Q99JX2;
DR  UNIPROT: Q9D0W3;
DR  Pfam: PF02114;
DE  Function: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity). {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000250|UniProtKB:Q9H2J4, ECO:0000269|PubMed:26059764}.
DE  Reference Proteome: Yes;
DE  Interaction: P68510; IntAct: EBI-8586548; Score: 0.35
DE  Interaction: P35279; IntAct: EBI-11566531; Score: 0.35
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0097356;
GO  GO:0032991;
GO  GO:0044183;
GO  GO:0043184;
GO  GO:0030036;
GO  GO:0001525;
GO  GO:0006915;
GO  GO:0034605;
GO  GO:0061077;
GO  GO:1903645;
GO  GO:2000059;
GO  GO:0045766;
GO  GO:0001938;
GO  GO:0010628;
GO  GO:0006457;
GO  GO:0050821;
GO  GO:0050730;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MQDPNADTEWNDILRKKGILPPKESLKELEEEEAEKEEQLLQQSVVKTYEDMTLEELEENEDEFSEEDERAIEMYRQQRL
SQ  AEWKATQLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCSLINHHLSGLARKFPDVKFIKAISTTCIPNYP
SQ  DRNLPTVFVYREGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTALEENPKKPIQDLLLSSVRGPVPMRRDSDSEDD
//