ID  Q8BWR8;
PN  Rhophilin-2;
GN  Rhpn2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}.
DR  UNIPROT: Q8BWR8;
DR  UNIPROT: Q9DBN2;
DR  PDB: 1VAE;
DR  Pfam: PF03097;
DR  Pfam: PF02185;
DR  PROSITE: PS51180;
DR  PROSITE: PS50106;
DR  PROSITE: PS51860;
DE  Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0003094;
GO  GO:0051497;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTDTLLPAAPQPLEKEGDDYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNQKVREQVRLELSFV
SQ  NSDLQMLKEELEGLNISVGVYQGTEEAFTIPLIPLGLKETKEVDFSIVFKDFILEHYSEDSYLYEDDIADLMDLRQACRT
SQ  PSRDEAGVELLMSYFIQLGFVESRFFPPTRHMGLLFTWYDSFTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQA
SQ  GLESAVDAFQRAAGVLNYLKETFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKVCLPGIQNEFFVLVKVAQEAAKVAEA
SQ  YRQLHAAMSQEPVKENIPYSWASVAYVKAYHYGALAHYFAATLLIDHQLKPGADEDHQEKCLSQLYDRMPEGMTPLATLK
SQ  NAGQRVLLGKGHLHRAIGFHEESLREANLCKKLRDIQVLRDVLSAAHQRTQLKHTQHREDDDLLNLIDAPDVLPKTEREV
SQ  KITFPDFSKVTVTDFFQKLGPLSVFSASKRWSPPRGIHFTVEEGDLGFTLRGNTPVQVHFLDPHCSASLAGAKEGDYIVS
SQ  IQGVDCKWLTVSEVMKLLKSFGGEEVEMKVVSLLDSTSSMHNKCATYSVGMQKTYSMICLSMDDDDKADKTKKISKKLSF
SQ  LSWGTSKNRQKSASTLCLPEVGLARSQNKKKLPTPFSLLNSDSSLY
//