ID  Q8BXL9;
PN  Non-homologous end joining factor IFFO1;
GN  Iffo1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus {ECO:0000250|UniProtKB:Q0D2I5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q0D2I5}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q0D2I5}. Nucleus matrix {ECO:0000250|UniProtKB:Q0D2I5}. Note=Mainly soluble, the remaining is localized in the nuclear matrix. Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures. {ECO:0000250|UniProtKB:Q0D2I5}.
DR  UNIPROT: Q8BXL9;
DR  UNIPROT: Q3TQI1;
DR  UNIPROT: Q6PFE6;
DR  UNIPROT: Q8BXS3;
DR  UNIPROT: Q8C1D6;
DR  PROSITE: PS51842;
DE  Function: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that will relocalize to the DSB sites in a XRCC4- dependent manner and promote the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). {ECO:0000269|PubMed:31548606}.
DE  Reference Proteome: Yes;
GO  GO:0005882;
GO  GO:0005637;
GO  GO:0016363;
GO  GO:0005654;
GO  GO:0035861;
GO  GO:1990683;
GO  GO:0006303;
GO  GO:1990166;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MNPLFGPNLFLLQQEQQGLAGPLGDPLGGDHFAGGGDLASAPLASAGPSAYSPPGPGPAPPAAMALRNDLGSNINVLKTL
SQ  NLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLARRDQAVQTGFISPIRPLGLPLSSRPAAVCPPSARVLGSPS
SQ  RSPAGPLASSAACHTSSSTSTSTAFSSSTRFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRA
SQ  LYNVLAKVKRERDEYKRRWEEEYTVRIQLQERVTELQEEAQEADACQEELAMKVEQLKAELVVFKGLMSNNLTELDTKIQ
SQ  EKAMKVDMDICRRIDITAKLCDLAQQRNCEDMIQMFQKKLVPSMGGRKRERKAAVEEDTSLSESDGPRQPEGAEEESTAL
SQ  SINEEMQRMLSQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETI
SQ  DQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSETEDSDRDVSSDSS
SQ  MR
//