ID  Q8C0T0;
PN  XK-related protein 8, processed form;
GN  Xkr8;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:25231987}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9H6D3}.
DR  UNIPROT: Q8C0T0;
DR  Pfam: PF09815;
DE  Function: [XK-related protein 8, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:25231987, PubMed:27503893, PubMed:29440417, PubMed:30718401). Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:23845944, PubMed:29440417, PubMed:30718401, PubMed:31712393). Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina (PubMed:30559640, PubMed:29440417, PubMed:31712393). Has no effect on calcium-induced exposure of phosphatidylserine (By similarity). Promotes myoblast differentiation and survival (PubMed:28881496). {ECO:0000250|UniProtKB:Q9H6D3, ECO:0000269|PubMed:23845944, ECO:0000269|PubMed:25231987, ECO:0000269|PubMed:27503893, ECO:0000269|PubMed:28881496, ECO:0000269|PubMed:29440417, ECO:0000269|PubMed:30559640, ECO:0000269|PubMed:30718401, ECO:0000269|PubMed:31712393}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0017128;
GO  GO:1902742;
GO  GO:0043652;
GO  GO:0051649;
GO  GO:0097350;
GO  GO:0070782;
GO  GO:0045663;
GO  GO:0002513;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MPLSVHHHVALDVVVGLVSILSFLLDLVADLWAVVQYVLLGRYLWAALVLVLLGQASVLLQLFSWLWLTADPTELHHSQL
SQ  SRPFLALLHLLQLGYLYRCLHGMHQGLSMCYQEMPSECDLAYADFLSLDISMLKLFESFLEATPQLTLVLAIVLQNGQAE
SQ  YYQWFGISSSFLGISWALLDYHRSLRTCLPSKPRLGRSSSAIYFLWNLLLLGPRICAIALFSAVFPYYVALHFFSLWLVL
SQ  LFWIWLQGTNFMPDSKGEWLYRVTMALILYFSWFNVSGGRTRGRAVIHLIFIFSDSVLLVTTSWVTHGTWLPSGISLLMW
SQ  VTIGGACFFLGLALRVIYYLWLHPSCSWDPDLVDGTLGLLSPHRPPKLIYNRRATLLAENFFAKAKARAVLTEEVQLNGV
SQ  L
//