ID  Q8C2S5;
PN  F-box/LRR-repeat protein 5;
GN  Fbxl5;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}.
DR  UNIPROT: Q8C2S5;
DR  UNIPROT: Q14CG1;
DR  UNIPROT: Q3TAK6;
DR  UNIPROT: Q3TWC9;
DR  UNIPROT: Q3UC66;
DR  UNIPROT: Q80XI5;
DR  UNIPROT: Q8BGF5;
DR  UNIPROT: Q8BNL3;
DR  UNIPROT: Q8C3Q8;
DR  Pfam: PF12937;
DR  Pfam: PF01814;
DR  Pfam: PF13516;
DR  PROSITE: PS50181;
DE  Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0048471;
GO  GO:0019005;
GO  GO:0005506;
GO  GO:0055072;
GO  GO:0045732;
GO  GO:0030163;
GO  GO:0016567;
GO  GO:0031146;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVH
SQ  SDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCS
SQ  QKDTAELLRGLSLWNQAEERQKVLKYSVDEKADTEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAK
SQ  TGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRNRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRVLHGL
SQ  IHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDMA
SQ  LEKISRALGVLTSHQSGFLKSAGKAASTPWTSKDITMPSTTQYACLHNLTDKGIGEEIDNEHSWTEPVSSESLTSPYVWM
SQ  LDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMT
SQ  TLPATSAMCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRALTLGGGLPYLEHLNLSGCLTVTG
SQ  AGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE
//