ID  Q8CGY6;
PN  Protein unc-45 homolog B;
GN  Unc45b;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:Q8IWX7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000269|PubMed:18478096}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {ECO:0000250|UniProtKB:Q6DGE9}.
DR  UNIPROT: Q8CGY6;
DR  UNIPROT: Q5XG72;
DR  UNIPROT: Q8BHC5;
DR  UNIPROT: Q8BWK3;
DR  Pfam: PF11701;
DR  PROSITE: PS50005;
DR  PROSITE: PS50293;
DE  Function: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development (PubMed:12356907, PubMed:18326487, PubMed:18478096). Is necessary for normal early lens development (By similarity). {ECO:0000250|UniProtKB:Q6DGE9, ECO:0000269|PubMed:12356907, ECO:0000269|PubMed:18326487, ECO:0000269|PubMed:18478096}.
DE  Reference Proteome: Yes;
DE  Interaction: P97414; IntAct: EBI-20564572; Score: 0.35
DE  Interaction: P51637; IntAct: EBI-20565496; Score: 0.35
GO  GO:0031672;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0030018;
GO  GO:0051879;
GO  GO:0030154;
GO  GO:0061077;
GO  GO:0002088;
GO  GO:0007517;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKAL
SQ  YRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQLRVQFSTDSRVQTMFEILLNENSEADKREKAAN
SQ  NLIVLGREEAGAERIFQSNGVALLLQLMNTQRPELLLAAVRTLSGMCSGHRARATAILHAVRIDRICSLMALENEEMSLA
SQ  VCNLLQAIIDSLSGEDKREHRGKEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQALNLLNKNVPRKDLSIHDNSRT
SQ  IYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHFRKICEEYITSKFDPQDMDKNVNAIQ
SQ  TVSGILQGPFDLGNQLLGMKGVMEMMVALCGSEREADQLVAVEALIHASTKLSRATFIITNGVTLLKQIYKTTKNEKIKI
SQ  RTLVGLCKLGSAGGSDYGLRQFAEGSTEKLAKQCRKWLCNTAIDTRTRRWAVEGLAYLTLDADVKDDFVQDIPALQAMFE
SQ  LAKARTSDKTILYSVANTLVNCTNSYDVKEVVPELVQLAKFSKQHVPEEHPKDKKDFVDLRVKRLLKAGVISALACMVKA
SQ  DSAILTDQTKELLARVFLALCDNPKDRGTIVAQGGGKALIPLALEGTDVGKVKAAHGLAKIAAVSNPDIAFPGERVYEVV
SQ  RPLVSLLDTQRDGLQNYEALLGLTNLSGRSDKLRQKIFKEKALPDIENYMFENHDQLRQAATECMCNMVLNKEVQERFLA
SQ  DGNDRLKLVVLLCGEDDHKLQNAAAGALAMLTAAHKKLCLKMTEVTTQWLEILQRLCLHDQLSVQHRGLVIAHNLLSADA
SQ  ELARKLVESELLEILTVVGKQEPDEKRAAVVQTARECLIKCMDYGFIKPVS
//