ID  Q8CHC4;
PN  Synaptojanin-1;
GN  Synj1;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}.
DR  UNIPROT: Q8CHC4;
DR  Pfam: PF08952;
DR  Pfam: PF03372;
DR  Pfam: PF02383;
DR  PROSITE: PS50102;
DR  PROSITE: PS50275;
DE  Function: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (By similarity). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). {ECO:0000250|UniProtKB:O18964, ECO:0000250|UniProtKB:O43426}.
DE  Reference Proteome: Yes;
DE  Interaction: Q96B97; IntAct: EBI-6953809; Score: 0.52
DE  Interaction: P63101; IntAct: EBI-2255635; Score: 0.35
DE  Interaction: P50516; IntAct: EBI-6272793; Score: 0.35
DE  Interaction: F6SEU4; IntAct: EBI-16733301; Score: 0.53
DE  Interaction: Q62108; IntAct: EBI-16724752; Score: 0.35
DE  Interaction: Q83BP6; IntAct: EBI-21287354; Score: 0.37
DE  Interaction: Q6P1J9; IntAct: EBI-20726660; Score: 0.35
DE  Interaction: Q6NZM9; IntAct: EBI-26472902; Score: 0.35
GO  GO:0030118;
GO  GO:0030132;
GO  GO:0005737;
GO  GO:0098978;
GO  GO:0030117;
GO  GO:0005874;
GO  GO:0043005;
GO  GO:0098688;
GO  GO:0048471;
GO  GO:0098794;
GO  GO:0098793;
GO  GO:0032991;
GO  GO:0098685;
GO  GO:0097060;
GO  GO:0043195;
GO  GO:0012506;
GO  GO:1990175;
GO  GO:0052658;
GO  GO:0034595;
GO  GO:0004438;
GO  GO:0004439;
GO  GO:0043812;
GO  GO:0008022;
GO  GO:0044877;
GO  GO:0003723;
GO  GO:0017124;
GO  GO:0007420;
GO  GO:0046855;
GO  GO:0007612;
GO  GO:0006836;
GO  GO:0046856;
GO  GO:0046488;
GO  GO:0048015;
GO  GO:1904980;
GO  GO:0014015;
GO  GO:0048260;
GO  GO:1903423;
GO  GO:0098884;
GO  GO:0099149;
GO  GO:0034097;
GO  GO:0032526;
GO  GO:0048488;
GO  GO:0016082;
GO  GO:0048489;
GO  GO:0016191;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYAKVLDAYGLLGVLRLNLGDTMLHYLVL
SQ  VTGCMSVGKIQESEVFRVTSTEFISLRVDASDEDRISEVRKVLNSGNFYFAWSASGVSLDLSLNAHRSMQEHTTDNRFFW
SQ  NQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIYLD
SQ  DCVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKDLYGKQIVVNLLGSKEGEHMLSKAFQSHLK
SQ  ASEHASDIHMVSFDYHQMVKGGKAEKLHSILKPQVQKFLDYGFFYFDGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLE
SQ  MLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL
SQ  LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTD
SQ  WLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVNASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFV
SQ  FIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEIARKLSFPMGRMLF
SQ  SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKYDLFSEDYDTSEKCR
SQ  TPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQK
SQ  IYKEVIAVQGPPDGTVLVSIKSSAQESTFFDDALIDELLRQFAHFGEVILIRFVEDKMWVTFLEGSSALNALSLNGKELL
SQ  NRTITITLKSPDWIKHLEEEMSLEKISVTLPSSASSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGT
SQ  SPSSSPRTSPCQSPTVPEYSAPSLPIRPSRAPSRTPGPPSSQGSPVDTQPAAQKDSSQTLEPKRPPPPRPVAPPARPAPP
SQ  QRPPPPSGARSPAPARKEFGGVGAPPSPGVARREIEAPKSPGTARKDNIGRNQPSPQAGLAGPGPAGYGAARPTIPARAG
SQ  VISAPQSQARVCAGRPTPDSQSKPSETLKGPAVLPEPLKPQAAFPQQPSLPTPAQKLQDPLVPIAAPTMPPSGPQPNLET
SQ  PPQPPPRSRSSQSLPSDSSPQLQQEQPTGQVKINGISGVKQEPTLKSDPFEDLSLSVLAVSKAQPSVQISPVLTPDPKML
SQ  IQLPSASQSQVNPLSSVSCMPTRPPGPEESKSQESMGSSANPFPSLPCRNPFTDRTAAPGNPFRVQSQESEATSWLSKEE
SQ  PVPNSPFPPLMPLSHDTSKASSSLGGFEDNFDLQSQSTVKTSNPKGWVTFDEDDNFPTTGKSKSVCPDLVGNAPASFDDD
SQ  WSKGASVSFCVLPARRPPPPPPPVPLLPPGTTSSAGPSTTLPSKAPSTLDFTER
//