ID  Q8CHM1;
PN  Aquaporin-11;
GN  Aqp11;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8NBQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NBQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Cell membrane {ECO:0000250|UniProtKB:Q8NBQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBQ7}. Cytoplasm {ECO:0000250|UniProtKB:Q8BHH1}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BHH1}. Note=Localizes mainly to the periphery of lipid droplets. it accumulates partly in mitochondrial-associated endoplasmic reticulum membranes. {ECO:0000250|UniProtKB:Q8NBQ7}.
DR  UNIPROT: Q8CHM1;
DR  UNIPROT: Q6AZ79;
DR  Pfam: PF00230;
DE  Function: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development (By similarity). {ECO:0000250|UniProtKB:Q8BHH1, ECO:0000250|UniProtKB:Q8NBQ7}.
DE  Reference Proteome: Yes;
GO  GO:0009986;
GO  GO:0005737;
GO  GO:0030659;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0015267;
GO  GO:0015254;
GO  GO:0042802;
GO  GO:0015250;
GO  GO:0009992;
GO  GO:0048388;
GO  GO:0015793;
GO  GO:0080170;
GO  GO:0001822;
GO  GO:0050680;
GO  GO:1904293;
GO  GO:1903573;
GO  GO:0032364;
GO  GO:0008284;
GO  GO:0006486;
GO  GO:0051260;
GO  GO:0006612;
GO  GO:0072014;
GO  GO:0055085;
GO  GO:0030104;
GO  GO:0006833;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSALLGLPPEVQDTCISLGLMLLVVLFMGLARVIARQQLHRPMVHAFVLEFLATFQLCYCTHELQLLSEQDSGHPTWTLT
SQ  LIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLMAQLVSALCSRYCISALWSLSLTKYHFDERILACRNPIN
SQ  TDISKAIIIEAICSFIFHSALLHFQEVRTKLRIHVLAALITFLAYAGGSLTGALFNPALALSLHFPCFDESFYKFFVVYW
SQ  VAPSLGVLLMILMFSFFLPWLHNNQLSNKKE
//