ID  Q8HZJ2;
PN  Prostaglandin E synthase;
GN  PTGES;
OS  9796;
SL  Nucleus Position: SL-0198;
SL  Comments: Membrane {ECO:0000250|UniProtKB:O14684}; Multi- pass membrane protein {ECO:0000250|UniProtKB:O14684}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O14684}. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000250|UniProtKB:O14684}.
DR  UNIPROT: Q8HZJ2;
DR  Pfam: PF01124;
DE  Function: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15- hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4- dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity). {ECO:0000250|UniProtKB:O14684, ECO:0000250|UniProtKB:Q9JM51}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0005641;
GO  GO:0048471;
GO  GO:0043295;
GO  GO:0004602;
GO  GO:0004364;
GO  GO:0004667;
GO  GO:0050220;
GO  GO:0008283;
GO  GO:0008285;
GO  GO:0032308;
GO  GO:0001516;
GO  GO:0031620;
GO  GO:0050727;
GO  GO:0019233;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:O14684};
SQ  MPPPSLAMVSGQALPAFLLCSTLLVIKMYAVAVITGQVRLRKKAFANPEDALRHGGLQFHRDDQDVERCLRAHRNDMETI
SQ  YPFLFLGLVYSFLGPDPFVAQMHFLVFFLGRMVHTVAYLGKLRAPTRSLAYTVAQLPCASMALQIVWEAARHL
//