ID  Q8IUC4;
PN  Rhophilin-2;
GN  RHPN2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12473120}.
DR  UNIPROT: Q8IUC4;
DR  UNIPROT: B2RCG8;
DR  UNIPROT: B3KUY8;
DR  UNIPROT: B4DUS7;
DR  UNIPROT: Q8N3T7;
DR  UNIPROT: Q8N9D6;
DR  UNIPROT: Q8NE33;
DR  UNIPROT: Q96RU1;
DR  PDB: 2VSV;
DR  Pfam: PF03097;
DR  Pfam: PF02185;
DR  PROSITE: PS51180;
DR  PROSITE: PS51860;
DR  OMIM: 617932;
DR  DisGeNET: 85415;
DE  Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity. {ECO:0000269|PubMed:12221077}.
DE  Reference Proteome: Yes;
DE  Interaction: P40337; IntAct: EBI-1059874; Score: 0.00
DE  Interaction: Q9UBN6; IntAct: EBI-1062633; Score: 0.00
DE  Interaction: P10321; IntAct: EBI-1064255; Score: 0.00
DE  Interaction: P20823; IntAct: EBI-1073373; Score: 0.00
DE  Interaction: Q9UET6; IntAct: EBI-1074557; Score: 0.00
DE  Interaction: Q9H1Y0; IntAct: EBI-1074608; Score: 0.00
DE  Interaction: Q9Y4K3; IntAct: EBI-1081405; Score: 0.00
DE  Interaction: P31947; IntAct: EBI-7543847; Score: 0.40
DE  Interaction: P13631; IntAct: EBI-3921027; Score: 0.37
DE  Interaction: O43521; IntAct: EBI-21803818; Score: 0.35
DE  Interaction: Q9BU70; IntAct: EBI-21872745; Score: 0.35
DE  Interaction: P61981; IntAct: EBI-21905461; Score: 0.35
DE  Interaction: Q04917; IntAct: EBI-21907689; Score: 0.35
DE  Interaction: Q5EP34; IntAct: EBI-25773054; Score: 0.35
DE  Interaction: P0DTC9; IntAct: EBI-26974147; Score: 0.40
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0003094;
GO  GO:0051497;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTDALLPAAPQPLEKENDGYFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNSKVREQVRLELSFV
SQ  NSDLQMLKEELEGLNISVGVYQNTEEAFTIPLIPLGLKETKDVDFAVVLKDFILEHYSEDGYLYEDEIADLMDLRQACRT
SQ  PSRDEAGVELLMTYFIQLGFVESRFFPPTRQMGLLFTWYDSLTGVPVSQQNLLLEKASVLFNTGALYTQIGTRCDRQTQA
SQ  GLESAIDAFQRAAGVLNYLKDTFTHTPSYDMSPAMLSVLVKMMLAQAQESVFEKISLPGIRNEFFMLVKVAQEAAKVGEV
SQ  YQQLHAAMSQAPVKENIPYSWASLACVKAHHYAALAHYFTAILLIDHQVKPGTDLDHQEKCLSQLYDHMPEGLTPLATLK
SQ  NDQQRRQLGKSHLRRAMAHHEESVREASLCKKLRSIEVLQKVLCAAQERSRLTYAQHQEEDDLLNLIDAPSVVAKTEQEV
SQ  DIILPQFSKLTVTDFFQKLGPLSVFSANKRWTPPRSIRFTAEEGDLGFTLRGNAPVQVHFLDPYCSASVAGAREGDYIVS
SQ  IQLVDCKWLTLSEVMKLLKSFGEDEIEMKVVSLLDSTSSMHNKSATYSVGMQKTYSMICLAIDDDDKTDKTKKISKKLSF
SQ  LSWGTNKNRQKSASTLCLPSVGAARPQVKKKLPSPFSLLNSDSSWY
//