ID  Q8IWB9;
PN  Testis-expressed protein 2;
GN  TEX2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q06833}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q06833}; Multi- pass membrane protein {ECO:0000255}. Note=Enriched at the nucleus- vacuole junction (PubMed:22250200). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (By similarity). {ECO:0000250|UniProtKB:Q06833, ECO:0000269|PubMed:22250200}.
DR  UNIPROT: Q8IWB9;
DR  UNIPROT: Q6AHZ5;
DR  UNIPROT: Q8N3L0;
DR  UNIPROT: Q9C0C5;
DR  PROSITE: PS51847;
DR  OMIM: 619929;
DR  DisGeNET: 55852;
DE  Function: During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000269|PubMed:28011845}.
DE  Reference Proteome: Yes;
DE  Interaction: Q81KT8; IntAct: EBI-2820950; Score: 0.00
DE  Interaction: A0A5P8YCV0; IntAct: EBI-2852770; Score: 0.00
DE  Interaction: P01106; IntAct: EBI-3962281; Score: 0.35
DE  Interaction: P88995; IntAct: EBI-9641383; Score: 0.37
DE  Interaction: Q5JU00; IntAct: EBI-11385220; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11398030; Score: 0.27
DE  Interaction: P52799; IntAct: EBI-21582984; Score: 0.35
DE  Interaction: Q9H2J7; IntAct: EBI-21614809; Score: 0.35
DE  Interaction: Q96G30; IntAct: EBI-21633324; Score: 0.35
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.27
DE  Interaction: Q15388; IntAct: EBI-16801791; Score: 0.27
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P46108; IntAct: EBI-30820623; Score: 0.44
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0031965;
GO  GO:0008289;
GO  GO:0006869;
GO  GO:0007165;
GO  GO:0006665;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MTSLYGRHAEKTTDMPKPSAPKVHVQRSVSRDTIAIHFSASGEEEEEEEEEFREYFEEGLDDQSIVTGLEAKEDLYLEPQ
SQ  VGHDPAGPAASPVLADGLSVSQAPAILPVSKNTVKLLESPVPAAQVLSTVPLAVSPGSSSSGPLASSPSVSSLSEQKTSS
SQ  SSPLSSPSKSPILSSSASTSTLSSAKPFMSLVKSLSTEVEPKESPHPARHRHLMKTLVKSLSTDTSRQESDTVSYKPPDS
SQ  KLNLHLFKQFTQPRNTGGDSKTAPSSPLTSPSDTRSFFKVPEMEAKIEDTKRRLSEVIYEPFQLLSKIIGEESGSHRPKA
SQ  LSSSASELSNLSSLNGHLESNNNYSIKEEECDSEGDGYGSDSNIPRSDHPKSTGEPTREIELKSSQGSSLKDLGLKTSSL
SQ  VLEKCSLSALVSKEDEEFCELYTEDFDLETEGESKVDKLSDIPLKPEVLAEDGVVLDSEDEVDSAVQHPELPVKTLGFFI
SQ  MCVYVYLILPLPHYVSGLFLGIGLGFMTAVCVIWFFTPPSAHKYHKLHKNLRHWNTRSLDIKEPEILKGWMNEIYNYDPE
SQ  TYHATLTHSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLARKRIWNKKYPICIELG
SQ  QQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQRDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGV
SQ  SGGKPGLLPAHSRHNSPSGHLTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQSAE
SQ  SSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKIL
SQ  QAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDD
SQ  APEPSGGDKQLLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIPP
SQ  PPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQKVFVMPNMDDVYITIMHSAMDPRSTSCLLKDPP
SQ  VEAADQP
//