ID  Q8IWE4;
PN  DCN1-like protein 3;
GN  DCUN1D3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416}. Cytoplasm {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:26906416}. Nucleus {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:26906416}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18823379}. Note=After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556}.
DR  UNIPROT: Q8IWE4;
DR  UNIPROT: B3KVY4;
DR  PDB: 4GBA;
DR  Pfam: PF03556;
DR  PROSITE: PS51229;
DR  OMIM: 616167;
DR  DisGeNET: 123879;
DE  Function: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:23201271, PubMed:19617556, PubMed:27542266, PubMed:18823379). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:26906416, PubMed:25349211). {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:23201271, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416, ECO:0000269|PubMed:27542266}.
DE  Reference Proteome: Yes;
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q96Q27; IntAct: EBI-21879621; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-15794277; Score: 0.58
DE  Interaction: Q13617; IntAct: EBI-15794136; Score: 0.35
DE  Interaction: Q13616; IntAct: EBI-15794136; Score: 0.35
DE  Interaction: P61081; IntAct: EBI-15794345; Score: 0.44
DE  Interaction: Q16695; IntAct: EBI-20937612; Score: 0.40
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
GO  GO:0005737;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0000151;
GO  GO:0097602;
GO  GO:0031624;
GO  GO:0032182;
GO  GO:0030308;
GO  GO:2000134;
GO  GO:2000435;
GO  GO:0043065;
GO  GO:2000436;
GO  GO:0051443;
GO  GO:0045116;
GO  GO:0010564;
GO  GO:2000434;
GO  GO:0010332;
GO  GO:0010225;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Sequence Analysis;
SQ  MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESK
SQ  SNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSID
SQ  GICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISR
SQ  DTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT
//