ID  Q8IWQ3;
PN  Serine/threonine-protein kinase BRSK2;
GN  BRSK2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin.
DR  UNIPROT: Q8IWQ3;
DR  UNIPROT: B3KVE9;
DR  UNIPROT: E9PLM7;
DR  UNIPROT: O60843;
DR  UNIPROT: O95099;
DR  UNIPROT: Q5J5B4;
DR  UNIPROT: Q6ZMQ4;
DR  UNIPROT: Q8TB60;
DR  Pfam: PF00069;
DR  PROSITE: PS00107;
DR  PROSITE: PS50011;
DR  PROSITE: PS00108;
DR  OMIM: 609236;
DR  DisGeNET: 9024;
DE  Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr- 174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8WVZ9; IntAct: EBI-3232144; Score: 0.35
DE  Interaction: Q99PL5; IntAct: EBI-11066888; Score: 0.35
DE  Interaction: Q9Y4K3; IntAct: EBI-24471109; Score: 0.56
DE  Interaction: Q96RY5; IntAct: EBI-28942454; Score: 0.35
DE  Interaction: P61769; IntAct: EBI-28942454; Score: 0.35
DE  Interaction: P02452; IntAct: EBI-28942454; Score: 0.35
DE  Interaction: Q8TDC3; IntAct: EBI-28943702; Score: 0.35
DE  Interaction: Q92905; IntAct: EBI-30872909; Score: 0.64
GO  GO:0005813;
GO  GO:0005737;
GO  GO:0150034;
GO  GO:0005783;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0051117;
GO  GO:0060590;
GO  GO:0000287;
GO  GO:0019901;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0048156;
GO  GO:0050321;
GO  GO:0031532;
GO  GO:0007409;
GO  GO:0051301;
GO  GO:0042149;
GO  GO:0036503;
GO  GO:0030010;
GO  GO:0006887;
GO  GO:0000086;
GO  GO:0035556;
GO  GO:0070059;
GO  GO:0090176;
GO  GO:0030182;
GO  GO:0018105;
GO  GO:0006468;
GO  GO:0043462;
GO  GO:0050770;
GO  GO:0061178;
GO  GO:0010975;
GO  GO:1904152;
GO  GO:2000807;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLK
SQ  LHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADF
SQ  GMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP
SQ  PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQ
SQ  DLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPVPARRA
SQ  IEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRARLN
SQ  SIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSL
SQ  SHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEAQKENGIYSVTFTLLSGPSRRFKRVVETIQAQLLSTHDPP
SQ  AAQHLSDTTNCMEMMTGRLSKCGSPLSNFFDVIKQLFSDEKNGQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPTG
SQ  KDTAKMGPPTARREQP
//