ID  Q8K243;
PN  E3 ubiquitin-protein ligase TRIM68;
GN  Trim68;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6AZZ1}. Nucleus {ECO:0000250|UniProtKB:Q6AZZ1}. Note=Colocalized with AR in nucleus. {ECO:0000250|UniProtKB:Q6AZZ1}.
DR  UNIPROT: Q8K243;
DR  Pfam: PF13765;
DR  Pfam: PF00622;
DR  Pfam: PF00643;
DR  PROSITE: PS50188;
DR  PROSITE: PS50119;
DR  PROSITE: PS00518;
DR  PROSITE: PS50089;
DE  Function: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. {ECO:0000250|UniProtKB:Q6AZZ1}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0035035;
GO  GO:0042802;
GO  GO:0050681;
GO  GO:0042803;
GO  GO:0019901;
GO  GO:0061630;
GO  GO:0004842;
GO  GO:0008270;
GO  GO:0045087;
GO  GO:0010508;
GO  GO:0043123;
GO  GO:0051092;
GO  GO:0051865;
GO  GO:0000209;
GO  GO:0016567;
GO  GO:0060765;
GO  GO:0010468;
GO  GO:0032880;
GO  GO:0046596;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDPAVLMEAIVEEVNCPICMTFLREPVSISCGHTFCHSCLSGLWKLPGESQNLSYTCPLCRAPVKPRKLRPNWQLASVVD
SQ  KVRLLGFCMEMGLKTDVCDLHKEQLTMFCKEDDMVTCEACKQSPEHEAHSVVPIKDVAWEYKWKLQQALEHLRKEQEEAW
SQ  KLEVSEKEQAAIWKTQMERRKQSIRWEFEKYRQLLKEKELPCQQAEEEAAAAQASLEQEKGETASKLELRREAIIRQSQV
SQ  LWSMIVELEERSQRPVRWMLQGIQEALNRSESWTLQQLEPISLELKTDCRVLGLRETLKTFAVDVRLDPDTAYSRLVVSK
SQ  DRKSVHYGVTQQNLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCVENVDRKEVVYLSPRYGFWVIRLRK
SQ  GTEYRAGTDEYPLLPLTVPPHRVGIFLDYEAHDISFYNVTDGASHIFTFPCYPFPGRLLPYFSPCYSIDTNNTTPLTICT
SQ  LGGEG
//