ID  Q8K3I4;
PN  Rab effector MyRIP;
GN  Myrip;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:12221080}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7}. Melanosome {ECO:0000269|PubMed:11964381, ECO:0000269|PubMed:12221080}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. In insulin- secreting cells, associated with dense core secretory granules. {ECO:0000269|PubMed:11964381, ECO:0000269|PubMed:12221080}.
DR  UNIPROT: Q8K3I4;
DR  UNIPROT: A1L320;
DR  UNIPROT: A1L321;
DR  UNIPROT: Q8CFC0;
DR  UNIPROT: Q8K4H5;
DR  Pfam: PF02318;
DR  Pfam: PF04698;
DR  PROSITE: PS50916;
DE  Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release. {ECO:0000269|PubMed:17827149}.
DE  Reference Proteome: Yes;
GO  GO:0015629;
GO  GO:0016324;
GO  GO:0030864;
GO  GO:0031045;
GO  GO:0000145;
GO  GO:0042470;
GO  GO:0048471;
GO  GO:0001750;
GO  GO:0030667;
GO  GO:0045202;
GO  GO:0030133;
GO  GO:0003779;
GO  GO:0046872;
GO  GO:0017022;
GO  GO:0051018;
GO  GO:0031267;
GO  GO:0006886;
GO  GO:0032024;
GO  GO:0030050;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLAEENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRR
SQ  CGECKFSVCKSCCSYQKHEKLWVCCVCQQARLLRTQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGGL
SQ  FEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALRVAEEAIEEAISKAESHGDSLDKQNEASYLRDHKQELTEELAGTI
SQ  LQRIIRKQKDKAELRAEEEEPEWPRSQSGSVKARGEGTTAPPGRHKARATFRRSQSAFSFTMEDALKSGSAEAAPRSPKD
SQ  RAQRLLEEAALPSWRSMDGLDGTNLAPLLQSPDGNWMTLKDGSRQPPTRLLTKPKSGTFQALEVASSVTSAYDEIGSDSE
SQ  EDFDYSEALSKLCPPSQSRLKQPQPQPTQAQSSGQGPLATSPSNPEAMCSDSETSSTSSSREAGCRAKLSWLQRKAPKNP
SQ  AVEKMPLQGELDVNFNPQAAGGETSDSSDPEETLRTAERRARRWRRARVGPEESNRGLPSPGAHPRALHTAQVSDNVSET
SQ  DISNETQNSRSSTDSVEEKLRNRLYELAMKMSEKETSSGEDQESESKAEPKNQKGSLSSEENNQGVQEELKKKCSAVSLC
SQ  NISTEVLKVINATEELIAESAGPWEIPPVSTDRENGMFPLGTDQVRLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAAR
SQ  CIHSSTGETELADLEDQVAAAAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRRKL
SQ  PAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTGDTKDLMEPDLESAVMY
//