ID  Q8K3K8;
PN  Optineurin;
GN  Optn;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15607428}. Golgi apparatus {ECO:0000250|UniProtKB:Q96CV9}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Recycling endosome {ECO:0000250}. Note=Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3- positive cytoplasmic vesicles upon induction of autophagy (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q96CV9}.
DR  UNIPROT: Q8K3K8;
DR  UNIPROT: A2ASP3;
DR  PDB: 5WQ4;
DR  Pfam: PF16516;
DR  Pfam: PF11577;
DR  PROSITE: PS51801;
DE  Function: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. {ECO:0000250|UniProtKB:Q96CV9, ECO:0000269|PubMed:26677802}.
DE  Reference Proteome: Yes;
DE  Interaction: Q3U0D9; IntAct: EBI-9683581; Score: 0.35
DE  Interaction: Q64337; IntAct: EBI-9683581; Score: 0.35
DE  Interaction: Q9WUN2; IntAct: EBI-12521947; Score: 0.40
GO  GO:0005776;
GO  GO:0030424;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0043025;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0055037;
GO  GO:0005802;
GO  GO:0042802;
GO  GO:0070530;
GO  GO:0046872;
GO  GO:0031593;
GO  GO:0008022;
GO  GO:0030674;
GO  GO:0031267;
GO  GO:0001155;
GO  GO:0043130;
GO  GO:0006914;
GO  GO:0034620;
GO  GO:0050829;
GO  GO:0007030;
GO  GO:0090161;
GO  GO:0043001;
GO  GO:0045087;
GO  GO:0008285;
GO  GO:0043124;
GO  GO:0043524;
GO  GO:0001920;
GO  GO:0061734;
GO  GO:0010508;
GO  GO:0008284;
GO  GO:0001819;
GO  GO:0010628;
GO  GO:2000179;
GO  GO:0043525;
GO  GO:1904417;
GO  GO:0008104;
GO  GO:0034067;
GO  GO:0043122;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSHQPLSCLTEKGDSPCETPGNGPSNMVHPSLDTFTPEELLQQMKELLVENHQLKEAMKLNNQAMKGRFEELSAWTEKQK
SQ  EERLLFEMQSKEVKERLKALTHENERLKEELGKFKEKSEKPLEDLTGGYRYPRALEEEVEKLKTQVEQEVEHLKIQVMRL
SQ  RAEKADLLGIVSELQLKLNSGGSSEDSFVEIRMTEGETEGAMKEMKNCPTPTRTDPISLSNCTEDARSCAEFEELTVSQL
SQ  LLCLREGNQKVERLEVALREAKERISDFEKKANGHSSTEKQTARRADREKEDKGQESVGSEVETLSIQVTSLFKELQEAH
SQ  TKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNKKLELQVESMRSEIKMEQAKTEEEKSRLATLQATHNKLL
SQ  QEHNKALKTIEELTKQQAEKVDKMLLQELSEKLELAEQALASKQLQMDEMKQTLAKQEEDLETMAVLRAQMEVYCSDFHA
SQ  ERAAREKIHEEKEQLALQLAILLKENNDIEEGGSRQSLMEMQCRHGARTSDSDQQTYLFQRGAEDRSWQHGQQPRSIPIH
SQ  SCPKCGEVLPDIDTLQIHVMDCII
//