ID  Q8MNV0;
PN  Spastin homolog;
GN  spas;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Membrane {ECO:0000255}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UBP0}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17531954}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17531954}. Note=Forms an intramembrane hairpin-like structure in the membrane (By similarity). Localizes to the cytoskeleton, perinuclear region and cytoplasm in early embryos (PubMed:17531954). {ECO:0000250|UniProtKB:Q9UBP0, ECO:0000269|PubMed:17531954}.
DR  UNIPROT: Q8MNV0;
DR  UNIPROT: G5EEF8;
DR  UNIPROT: Q7M3K5;
DR  UNIPROT: Q8MNU9;
DR  Pfam: PF00004;
DR  Pfam: PF17862;
DR  PROSITE: PS00674;
DE  Function: ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules (PubMed:17531954, PubMed:19619244, PubMed:22561316, PubMed:18202664). Probably by regulating microtubule remodeling, plays a role in new synapse formation in GABAergic DD (Dorsal D type) neurons (PubMed:26051896). {ECO:0000269|PubMed:17531954, ECO:0000269|PubMed:18202664, ECO:0000269|PubMed:19619244, ECO:0000269|PubMed:22561316, ECO:0000269|PubMed:26051896}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8MNV0; IntAct: EBI-15680282; Score: 0.62
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0016020;
GO  GO:0005874;
GO  GO:0015630;
GO  GO:0048471;
GO  GO:0032991;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0042802;
GO  GO:0016853;
GO  GO:0008017;
GO  GO:0008568;
GO  GO:0001578;
GO  GO:0007019;
GO  GO:0051013;
GO  GO:0007399;
GO  GO:0051647;
GO  GO:0048477;
GO  GO:0031117;
GO  GO:0040025;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q9UBP0};
SQ  MFAFSKGPAGSSTYDRVAQKFQDGYEKMRAAIEMDELTKHAGSIQEKLRTAELYKEARSLLKEANEFNIMDIPETRRSEI
SQ  RDKRQNMMKLEKSAQDRLIAICNEVDPNVKQSRSATVGPSRPASAARVTPRPTRATAPEKKNAAKAKENDENRHVCSRGD
SQ  RCGAHHQPVTKKSDTVHPEPPVQASNRKMETVKRVKVDKASLPMHQNPVNRAALLNGVDKVIGERLLDEVLDNTGVRMDD
SQ  VAGCHSAKAALEEAVILPALNPNLFKGLRQPVKGILLFGPPGNGKTLLAKAVAGESKQMFFNISASSLTSKWVGDSEKTI
SQ  RGLFQIARNAQPSIIFIDEIDSILCERSEKDAEVSRRMKTEFLVQFDGATSSADDRILVIGATNRPHELDDAVLRRFPKR
SQ  IMLNLPDEEARKELITKTLKKHNMMDGLISSDIRYIASNTSGFSNSDLVALCKEAAMVPIREIDRSKLSMTDGEKIRKIR
SQ  ASDFDTALRTIRPSTSQKIMSKLSDFSRSFGC
//