ID  Q8MQX9;
PN  Ankyrin repeat and LEM domain-containing protein 2 homolog;
GN  Ankle2;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum {ECO:0000269|PubMed:31735666}. Nucleus envelope {ECO:0000269|PubMed:31735666}. Cytoplasm {ECO:0000269|PubMed:31735666}. Note=In neuroblasts, recruited to the nuclear envelope at the initiation of mitosis and remains associated with it until the beginning of cytokinesis. {ECO:0000269|PubMed:31735666}.
DR  UNIPROT: Q8MQX9;
DR  UNIPROT: Q0KHR1;
DR  UNIPROT: Q9VX44;
DR  UNIPROT: X2JCC5;
DR  Pfam: PF13637;
DR  PROSITE: PS50297;
DR  PROSITE: PS50088;
DE  Function: Involved in brain development probably by regulating asymmetric division of neuroblasts (PubMed:31735666, PubMed:30550790, PubMed:25259927). Regulates neuroblast asymmetric cell division by controlling asymmetric protein localization of Mira, Baz, Par-6 and aPKC, and spindle alignment (PubMed:31735666). Also, regulates the localization of kinase Ball during mitosis, specifically maintaining Ball in the nucleus during interphase (PubMed:31735666). Required for proper ER and nuclear envelope morphology in neuroblasts (PubMed:31735666). {ECO:0000269|PubMed:25259927, ECO:0000269|PubMed:30550790, ECO:0000269|PubMed:31735666}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9VXY7; IntAct: EBI-9936142; Score: 0.35
GO  GO:0005737;
GO  GO:0012505;
GO  GO:0005783;
GO  GO:0005635;
GO  GO:0051721;
GO  GO:0055059;
GO  GO:0045167;
GO  GO:0000902;
GO  GO:0007029;
GO  GO:0042326;
GO  GO:0031468;
GO  GO:0035307;
GO  GO:0051653;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSTYFGVYIPTSKAGCFEGSVSQCIGSIAAVNIKPSNPASGSASVASGSPSGSAASVQTGNADDGSAATKYEDPDYPPDS
SQ  PLWLIFTEKSKALDILRHYKEARLREFPNLEQAESYVQFGFESIEALKRFCKAKPESKPIPIISGSGYKSSPTSTDNSCS
SQ  SSPTGNGSGFIIPLGSNSSMSNLLLSDSPTSSPSSSSNVIANGRQQQMQQQQQQQPQQPDVSGEGPPFRAPTKQELVEFR
SQ  KQIEGGHIDRVKRIIWENPRFLISSGDTPTSLKEGCRYNAMHICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCA
SQ  ALNISLLDYYLNMPDKGRGETPLHFAAKNGHVAMVEVLVSYPECKSLRNHEGKEPKEIICLRNANATHVTIKKLELLLYD
SQ  PHFVPVLRSQSNTLPPKVGQPFSPKDPPNLQHKADDYEGLSVDLAISALAGPMSREKAMNFYRRWKTPPRVSNNVMSPLA
SQ  GSPFSSPVKVTPSKSIFDRSAGNSSPVHSGRRVLFSPLAEATSSPKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRK
SQ  MKPDLFMAYRNNNSFDSPSLADDSQILDMSLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREYWDFLD
SQ  SFLDIGTTEGLARLEAYFLEKTEQQADKSETVWNFAHLHQYFDSMAGEQQQQLRKDKNEAAGATSPSAGVMTPYTCVEKS
SQ  LQVFAKRITKTLINKIGNMVSINDTLLCELKRLKSLIVSFKDDARFISVDFSKVHSRIAHLVASYVTHSQEVSVAMRLQL
SQ  LQMLRSLRQLLADERGREQHLGCVCASLLLMLEQAPTSAVHLPDTLKTEELCCAAWETEQCCACLWDANLSRKTSRRKRT
SQ  KSLRAAAVVQSQGQLQDTSGSTGSSALHASLGVGSTSLGASRVVASASKDAWRRQQSDDEDYDSDEQVIFFDCTNVTLPY
SQ  GSSSEDEENFRTPPQSLSPGISMDLEPRYELFIFGNEPTKRDLDVLNALSNVDIDKETLPHVYAWKTAMESYSCAEMNLF
SQ  PSPRNVKVQKPEPWYSGTSSSHNSQPLLHPKRLLATPKLNAVVSGRRGSGPLTAPVTPRLARTPSAASIQVASETNGESV
SQ  GTAVTPASPILSFAALTAATQSFQTPLNKVRGLFSQYRDQRSYNEGDTPLGNRN
//