ID  Q8N1F7;
PN  Nuclear pore complex protein Nup93;
GN  NUP93;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus membrane {ECO:0000250|UniProtKB:Q66HC5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q66HC5}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:9348540}. Nucleus envelope {ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}. Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore. {ECO:0000269|PubMed:9348540}.
DR  UNIPROT: Q8N1F7;
DR  UNIPROT: B3KPQ8;
DR  UNIPROT: Q14705;
DR  PDB: 5IJN;
DR  PDB: 5IJO;
DR  PDB: 7PER;
DR  Pfam: PF04097;
DR  OMIM: 614351;
DR  OMIM: 616892;
DR  DisGeNET: 9688;
DE  Function: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.
DE  Disease: Nephrotic syndrome 12 (NPHS12) [MIM:616892]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. NPHS12 inheritance is autosomal recessive. {ECO:0000269|PubMed:26878725}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: A0A142I5B9; IntAct: EBI-20626314; Score: 0.35
DE  Interaction: O43542; IntAct: EBI-11129266; Score: 0.35
DE  Interaction: P04626; IntAct: EBI-32721465; Score: 0.27
DE  Interaction: P0DTC7; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P49790; IntAct: EBI-11076796; Score: 0.35
DE  Interaction: P57740; IntAct: EBI-11160436; Score: 0.35
DE  Interaction: P63279; IntAct: EBI-11105225; Score: 0.35
DE  Interaction: Q14974; IntAct: EBI-11115566; Score: 0.35
DE  Interaction: Q6PFD9; IntAct: EBI-10994876; Score: 0.35
DE  Interaction: Q6ZMQ8; IntAct: EBI-32723474; Score: 0.27
DE  Interaction: Q6ZQH8; IntAct: EBI-2563113; Score: 0.56
DE  Interaction: Q80U93; IntAct: EBI-2555228; Score: 0.56
DE  Interaction: Q8BH74; IntAct: EBI-10997196; Score: 0.35
DE  Interaction: O75365; IntAct: EBI-1059612; Score: 0.00
DE  Interaction: Q9Y5J5; IntAct: EBI-1064828; Score: 0.00
DE  Interaction: P49662; IntAct: EBI-1066732; Score: 0.00
DE  Interaction: P01106; IntAct: EBI-3893169; Score: 0.56
DE  Interaction: Q9HC98; IntAct: EBI-1069660; Score: 0.00
DE  Interaction: Q13418; IntAct: EBI-1070407; Score: 0.00
DE  Interaction: P62330; IntAct: EBI-1071623; Score: 0.00
DE  Interaction: Q9HAW0; IntAct: EBI-1072446; Score: 0.00
DE  Interaction: O14908; IntAct: EBI-1073459; Score: 0.00
DE  Interaction: Q9Y478; IntAct: EBI-1076145; Score: 0.00
DE  Interaction: Q9BUV8; IntAct: EBI-1076761; Score: 0.00
DE  Interaction: Q15714; IntAct: EBI-1078435; Score: 0.00
DE  Interaction: Q99623; IntAct: EBI-1078910; Score: 0.00
DE  Interaction: O00422; IntAct: EBI-1079733; Score: 0.00
DE  Interaction: Q96T60; IntAct: EBI-1079805; Score: 0.00
DE  Interaction: Q9Y2Q3; IntAct: EBI-1080109; Score: 0.00
DE  Interaction: O76071; IntAct: EBI-1083915; Score: 0.00
DE  Interaction: Q8AZK7; IntAct: EBI-9632715; Score: 0.35
DE  Interaction: Q8IY92; IntAct: EBI-2371551; Score: 0.35
DE  Interaction: Q504Q3; IntAct: EBI-2513052; Score: 0.40
DE  Interaction: P24386; IntAct: EBI-2515120; Score: 0.40
DE  Interaction: Q9Z0E3; IntAct: EBI-2549710; Score: 0.35
DE  Interaction: O43918; IntAct: EBI-2550555; Score: 0.40
DE  Interaction: Q99459; IntAct: EBI-7954144; Score: 0.35
DE  Interaction: Q13286; IntAct: EBI-3248480; Score: 0.35
DE  Interaction: O00716; IntAct: EBI-7600105; Score: 0.35
DE  Interaction: P0DOE9; IntAct: EBI-6138583; Score: 0.35
DE  Interaction: P19320; IntAct: EBI-6189915; Score: 0.35
DE  Interaction: Q77M19; IntAct: EBI-6268389; Score: 0.35
DE  Interaction: Q13618; IntAct: EBI-21329068; Score: 0.35
DE  Interaction: Q9UKV0; IntAct: EBI-6598230; Score: 0.35
DE  Interaction: Q96DB2; IntAct: EBI-6598272; Score: 0.35
DE  Interaction: Q8WYP5; IntAct: EBI-9050350; Score: 0.40
DE  Interaction: Q96FW1; IntAct: EBI-10770028; Score: 0.35
DE  Interaction: Q9ERU9; IntAct: EBI-10999306; Score: 0.35
DE  Interaction: E9PUA5; IntAct: EBI-10999661; Score: 0.35
DE  Interaction: Q8VE37; IntAct: EBI-11043815; Score: 0.35
DE  Interaction: P63280; IntAct: EBI-11044140; Score: 0.35
DE  Interaction: Q9BVL2; IntAct: EBI-11077390; Score: 0.35
DE  Interaction: Q96EE3; IntAct: EBI-11086798; Score: 0.35
DE  Interaction: Q07797; IntAct: EBI-11108624; Score: 0.35
DE  Interaction: Q8NFH5; IntAct: EBI-11889606; Score: 0.37
DE  Interaction: O60733; IntAct: EBI-24312432; Score: 0.56
DE  Interaction: Q15777; IntAct: EBI-24327809; Score: 0.56
DE  Interaction: Q14982; IntAct: EBI-24419380; Score: 0.56
DE  Interaction: O43299; IntAct: EBI-24468599; Score: 0.56
DE  Interaction: Q9NV29; IntAct: EBI-24472902; Score: 0.56
DE  Interaction: P06465; IntAct: EBI-26504492; Score: 0.37
DE  Interaction: P56180; IntAct: EBI-14025693; Score: 0.35
DE  Interaction: Q921C5; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: Q9NWT8; IntAct: EBI-16786806; Score: 0.27
DE  Interaction: O15155; IntAct: EBI-16788067; Score: 0.27
DE  Interaction: Q96I36; IntAct: EBI-16791250; Score: 0.27
DE  Interaction: O14880; IntAct: EBI-16796348; Score: 0.27
DE  Interaction: P62491; IntAct: EBI-16797971; Score: 0.27
DE  Interaction: P51151; IntAct: EBI-16798325; Score: 0.27
DE  Interaction: O75880; IntAct: EBI-16799233; Score: 0.27
DE  Interaction: Q71U36; IntAct: EBI-16799705; Score: 0.27
DE  Interaction: O43493; IntAct: EBI-16800265; Score: 0.27
DE  Interaction: Q15388; IntAct: EBI-16801791; Score: 0.27
DE  Interaction: Q9NS69; IntAct: EBI-16802054; Score: 0.27
DE  Interaction: P36957; IntAct: EBI-20305285; Score: 0.35
DE  Interaction: P08559; IntAct: EBI-20306509; Score: 0.35
DE  Interaction: P00441; IntAct: EBI-20307497; Score: 0.35
DE  Interaction: A2A935; IntAct: EBI-21022882; Score: 0.35
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: Q9H1C4; IntAct: EBI-21266770; Score: 0.35
DE  Interaction: Q8N4T4; IntAct: EBI-25408280; Score: 0.35
DE  Interaction: Q14CB8; IntAct: EBI-25409097; Score: 0.35
DE  Interaction: Q8WUY9; IntAct: EBI-25411615; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: Q5EP34; IntAct: EBI-25772822; Score: 0.35
DE  Interaction: P52298; IntAct: EBI-26397631; Score: 0.35
DE  Interaction: P48431; IntAct: EBI-26574619; Score: 0.35
DE  Interaction: Q8N488; IntAct: EBI-27110926; Score: 0.35
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
DE  Interaction: Q05D32; IntAct: EBI-27113232; Score: 0.35
DE  Interaction: Q13283; IntAct: EBI-28955349; Score: 0.35
DE  Interaction: Q8TDD2; IntAct: EBI-29000537; Score: 0.35
DE  Interaction: P08047; IntAct: EBI-29385496; Score: 0.35
DE  Interaction: P30530; IntAct: EBI-32719959; Score: 0.27
DE  Interaction: P11362; IntAct: EBI-32721578; Score: 0.27
DE  Interaction: P22607; IntAct: EBI-32721979; Score: 0.27
DE  Interaction: P17948; IntAct: EBI-32722433; Score: 0.27
DE  Interaction: P36888; IntAct: EBI-32722567; Score: 0.27
DE  Interaction: P35916; IntAct: EBI-32722728; Score: 0.27
DE  Interaction: P35968; IntAct: EBI-32723270; Score: 0.27
DE  Interaction: Q8IWU2; IntAct: EBI-32723604; Score: 0.27
DE  Interaction: Q96Q04; IntAct: EBI-32723651; Score: 0.27
DE  Interaction: Q12866; IntAct: EBI-32723870; Score: 0.27
DE  Interaction: Q01973; IntAct: EBI-32725295; Score: 0.27
DE  Interaction: P08922; IntAct: EBI-32731758; Score: 0.27
DE  Interaction: Q02763; IntAct: EBI-32732012; Score: 0.35
GO  GO:0005813;
GO  GO:0005829;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0034399;
GO  GO:0005643;
GO  GO:0017056;
GO  GO:0006998;
GO  GO:0051292;
GO  GO:0006913;
GO  GO:0016973;
GO  GO:0060391;
GO  GO:0006606;
GO  GO:0060395;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q66HC5};
SQ  MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLGSRGLDISHISQRLES
SQ  LSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQ
SQ  ESEPSYISDVGPPGRSSLDNIEMAYARQIYIYNEKIVNGHLQPNLVDLCASVAELDDKSISDMWTMVKQMTDVLLTPATD
SQ  ALKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPAPLPGLQDGEVEGHPVWA
SQ  LIYYCMRCGDLLAASQVVNRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAVYCIIGRCDVT
SQ  DNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVLFLTAQFEAAVAFLF
SQ  RMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDS
SQ  QGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLE
SQ  LMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLV
SQ  PLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIEDRDSQLRSQARTLITFAGMIP
SQ  YRTSGDTNARLVQMEVLMN
//