ID  Q8NDT2;
PN  Putative RNA-binding protein 15B;
GN  RBM15B;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus, nucleoplasm {ECO:0000269|PubMed:16129689}. Nucleus speckle {ECO:0000269|PubMed:19586903}. Nucleus envelope {ECO:0000269|PubMed:19586903}. Note=Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. {ECO:0000269|PubMed:16129689}.
DR  UNIPROT: Q8NDT2;
DR  UNIPROT: A4QPG7;
DR  UNIPROT: Q6QE19;
DR  UNIPROT: Q9BV96;
DR  Pfam: PF00076;
DR  Pfam: PF07744;
DR  PROSITE: PS50102;
DR  PROSITE: PS50917;
DR  OMIM: 612602;
DR  DisGeNET: 29890;
DE  Function: RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6- methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903). {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:21044963, ECO:0000269|PubMed:27602518, ECO:0000305|PubMed:16129689}.
DE  Reference Proteome: Yes;
DE  Interaction: P04626; IntAct: EBI-25368403; Score: 0.37
DE  Interaction: P59595; IntAct: EBI-27129966; Score: 0.35
DE  Interaction: O00487; IntAct: EBI-737465; Score: 0.00
DE  Interaction: Q9H492; IntAct: EBI-3044058; Score: 0.35
DE  Interaction: P11161; IntAct: EBI-3916834; Score: 0.37
DE  Interaction: P63316; IntAct: EBI-3918552; Score: 0.37
DE  Interaction: Q8N8Y2; IntAct: EBI-3925656; Score: 0.37
DE  Interaction: Q8IVL1; IntAct: EBI-10269920; Score: 0.56
DE  Interaction: Q9UJX2; IntAct: EBI-10269936; Score: 0.56
DE  Interaction: Q15003; IntAct: EBI-11006706; Score: 0.35
DE  Interaction: Q96L14; IntAct: EBI-11022408; Score: 0.35
DE  Interaction: Q96FV9; IntAct: EBI-11034504; Score: 0.35
DE  Interaction: P43243; IntAct: EBI-11071398; Score: 0.35
DE  Interaction: Q86U44; IntAct: EBI-11136579; Score: 0.35
DE  Interaction: Q92997; IntAct: EBI-25257901; Score: 0.56
DE  Interaction: Q14627; IntAct: EBI-21561326; Score: 0.35
DE  Interaction: Q7Z4N8; IntAct: EBI-21583801; Score: 0.35
DE  Interaction: P36406; IntAct: EBI-21627506; Score: 0.35
DE  Interaction: Q9BWE0; IntAct: EBI-21627543; Score: 0.35
DE  Interaction: Q9BRX9; IntAct: EBI-21634215; Score: 0.35
DE  Interaction: Q9NZQ3; IntAct: EBI-21676174; Score: 0.35
DE  Interaction: Q86VM9; IntAct: EBI-21769401; Score: 0.35
DE  Interaction: Q96T37; IntAct: EBI-21889356; Score: 0.35
DE  Interaction: Q53GT1; IntAct: EBI-21889356; Score: 0.35
DE  Interaction: P61981; IntAct: EBI-21905461; Score: 0.35
DE  Interaction: Q04917; IntAct: EBI-21907689; Score: 0.35
DE  Interaction: P15659; IntAct: EBI-25768922; Score: 0.37
DE  Interaction: P03430; IntAct: EBI-25769351; Score: 0.37
DE  Interaction: P03427; IntAct: EBI-25769417; Score: 0.37
DE  Interaction: P14404; IntAct: EBI-21026252; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: Q9BYV2; IntAct: EBI-22027638; Score: 0.00
DE  Interaction: O60563; IntAct: EBI-25477219; Score: 0.35
DE  Interaction: O76071; IntAct: EBI-25477658; Score: 0.35
DE  Interaction: O76024; IntAct: EBI-25898596; Score: 0.56
DE  Interaction: P0DTC9; IntAct: EBI-27129711; Score: 0.35
DE  Interaction: P15130; IntAct: EBI-27131516; Score: 0.35
DE  Interaction: Q0ZME3; IntAct: EBI-27131755; Score: 0.35
DE  Interaction: Q6Q1R8; IntAct: EBI-27132003; Score: 0.35
DE  Interaction: K9N4V7; IntAct: EBI-27132270; Score: 0.35
DE  Interaction: P33469; IntAct: EBI-27132272; Score: 0.35
GO  GO:0005635;
GO  GO:0016607;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0036396;
GO  GO:0003729;
GO  GO:0003723;
GO  GO:0009048;
GO  GO:0006406;
GO  GO:0006397;
GO  GO:0000381;
GO  GO:0001510;
GO  GO:0008380;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MKRQSERDSSPSGRGSSSSAKRPREREREAEAGGRRAAHKASGGAKHPVPARARDKPRGSGSGGGGHRDGRGTGDANHRA
SQ  SSGRSSGSGAGGGGRGGKASGDPGASGMSPRASPLPPPPPPPGAEPACPGSSAAAPEYKTLLISSLSPALPAEHLEDRLF
SQ  HQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREARQHALARQLLLYDRPLKVEPVYLRGGGGSSRRSSSSSAAASTPP
SQ  PGPPAPADPLGYLPLHGGYQYKQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYGYP
SQ  AVCEEDLMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSGR
SQ  VIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQYESLDAAQAACAKMRGFPLGG
SQ  PDRRLRVDFAKAEETRYPQQYQPSPLPVHYELLTDGYTRHRNLDADLVRDRTPPHLLYSDRDRTFLEGDWTSPSKSSDRR
SQ  NSLEGYSRSVRSRSGERWGADGDRGLPKPWEERRKRRSLSSDRGRTTHSPYEERSRTKGSGQQSERGSDRTPERSRKENH
SQ  SSEGTKESSSNSLSNSRHGAEERGHHHHHHEAADSSHGKKARDSERNHRTTEAEPKPLEEPKHETKKLKNLSEYAQTLQL
SQ  GWNGLLVLKNSCFPTSMHILEGDQGVISSLLKDHTSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLATQAT
SQ  PSGLGTEGMPTVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDGTGMLYAFPPCDFSQQYLQSALRTLGKLEEEH
SQ  MVIVIVRDTA
//