ID  Q8NFW9;
PN  Rab effector MyRIP;
GN  MYRIP;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:Q8K3I4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TNY7}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q7TNY7}. Note=In presynaptic and postsynaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments. {ECO:0000250|UniProtKB:Q7TNY7}.
DR  UNIPROT: Q8NFW9;
DR  UNIPROT: B3KWM3;
DR  UNIPROT: B3KWW4;
DR  UNIPROT: B7Z2H1;
DR  UNIPROT: B7Z9V3;
DR  UNIPROT: G3XAI8;
DR  UNIPROT: Q32M41;
DR  UNIPROT: Q32M42;
DR  UNIPROT: Q569F7;
DR  UNIPROT: Q8IUF5;
DR  UNIPROT: Q9Y3V4;
DR  Pfam: PF02318;
DR  Pfam: PF04698;
DR  PROSITE: PS50916;
DR  OMIM: 611790;
DR  DisGeNET: 25924;
DE  Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P62993; IntAct: EBI-1964454; Score: 0.40
DE  Interaction: P16333; IntAct: EBI-1969161; Score: 0.40
DE  Interaction: P27986; IntAct: EBI-1970169; Score: 0.40
DE  Interaction: P31016; IntAct: EBI-7970723; Score: 0.44
DE  Interaction: Q8TAB5; IntAct: EBI-10271494; Score: 0.72
DE  Interaction: O43482; IntAct: EBI-24530905; Score: 0.56
DE  Interaction: O00194; IntAct: EBI-24438904; Score: 0.56
DE  Interaction: P51159; IntAct: EBI-24457942; Score: 0.56
DE  Interaction: Q03135; IntAct: EBI-15800555; Score: 0.40
GO  GO:0030864;
GO  GO:0031045;
GO  GO:0000145;
GO  GO:0042470;
GO  GO:0048471;
GO  GO:0001750;
GO  GO:0045202;
GO  GO:0030133;
GO  GO:0003779;
GO  GO:0017022;
GO  GO:0051018;
GO  GO:0031267;
GO  GO:0008270;
GO  GO:0006886;
GO  GO:0032024;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFVEHCCMRCCSPFTFLVNTKRQ
SQ  CGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSL
SQ  FESNLENEGSISGSDSTFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTI
SQ  LQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQ
SQ  GQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEED
SQ  FDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAP
SQ  RNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDL
SQ  SETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAV
SQ  SLCNISTEVLKVINATEELIAGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELED
SQ  AARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTRRRDQKQRTQVQTIDTSRQQR
SQ  RKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKERKGTTKDLMEPALESAVMY
//