ID  Q8NHR7;
PN  Telomere repeats-binding bouquet formation protein 2;
GN  TERB2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Chromosome, telomere {ECO:0000250|UniProtKB:Q9D494}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D494}. Note=Localizes to telomeres throughout meiotic prophase I and disappears in metaphase I. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D494}.
DR  UNIPROT: Q8NHR7;
DR  PDB: 6GNX;
DR  PDB: 6GNY;
DR  PDB: 6J07;
DR  PDB: 6J08;
DR  Pfam: PF15101;
DR  OMIM: 617131;
DR  OMIM: 619645;
DE  Function: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. {ECO:0000250|UniProtKB:Q9D494}.
DE  Disease: Spermatogenic failure 59 (SPGF59) [MIM:619645]: An autosomal recessive male infertility disorder characterized by non-obstructive azoospermia, due to sperm maturation arrest. {ECO:0000269|PubMed:33377991}. Note=The disease may be caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: Q3KP22; IntAct: EBI-23751777; Score: 0.56
GO  GO:0000781;
GO  GO:0005637;
GO  GO:0007129;
GO  GO:0070197;
GO  GO:0045141;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFQGQRGWFCGSVSQDLRQFWVAEGGTISDPRAADFLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANAKIKNS
SQ  VALGHFILPPACLQKEIRRKIGSFIWEQDQHFLIEKHDEVTPNEIKTLRENSELATEHKKELSKSPEKHFIRTPVVEKQM
SQ  YFPLQNYPVNNMVTGYISIDAMKKFLGELHDFIPGTSGYLAYHVQNEINMSAIKNKLKRK
//