ID  Q8NI35;
PN  InaD-like protein;
GN  PATJ;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell junction, tight junction {ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:11964389, ECO:0000269|PubMed:12021270, ECO:0000269|PubMed:19755384, ECO:0000269|PubMed:22006950}. Apical cell membrane {ECO:0000269|PubMed:11964389}; Peripheral membrane protein {ECO:0000269|PubMed:11964389}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18596123}. Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (PubMed:11964389). Localized in the paranodal region of myelinating Schwann cells (By similarity). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7}.
DR  UNIPROT: Q8NI35;
DR  UNIPROT: O15249;
DR  UNIPROT: O43742;
DR  UNIPROT: O60833;
DR  UNIPROT: Q5VUA5;
DR  UNIPROT: Q5VUA6;
DR  UNIPROT: Q5VUA7;
DR  UNIPROT: Q5VUA8;
DR  UNIPROT: Q5VUA9;
DR  UNIPROT: Q5VUB0;
DR  UNIPROT: Q8WU78;
DR  UNIPROT: Q9H3N9;
DR  PDB: 1VF6;
DR  PDB: 2D92;
DR  PDB: 2DAZ;
DR  PDB: 2DB5;
DR  PDB: 2DLU;
DR  PDB: 2DM8;
DR  PDB: 2DMZ;
DR  PDB: 2EHR;
DR  PDB: 4Q2N;
DR  PDB: 6IRD;
DR  Pfam: PF09045;
DR  Pfam: PF00595;
DR  PROSITE: PS51022;
DR  PROSITE: PS50106;
DR  OMIM: 603199;
DE  Function: Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:16678097, ECO:0000269|PubMed:22006950}.
DE  Reference Proteome: Yes;
DE  Interaction: O94827; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: P35240; IntAct: EBI-3957523; Score: 0.50
DE  Interaction: Q66T02; IntAct: EBI-25409900; Score: 0.35
DE  Interaction: O95049; IntAct: EBI-8417397; Score: 0.56
DE  Interaction: O95832; IntAct: EBI-8417417; Score: 0.40
DE  Interaction: Q9NVP1; IntAct: EBI-736550; Score: 0.00
DE  Interaction: Q8N3R9; IntAct: EBI-8222553; Score: 0.72
DE  Interaction: Q8JZS0; IntAct: EBI-8230712; Score: 0.40
DE  Interaction: P82279; IntAct: EBI-8230772; Score: 0.50
DE  Interaction: Q9NPB6; IntAct: EBI-7053672; Score: 0.40
DE  Interaction: O00254; IntAct: EBI-7206220; Score: 0.46
DE  Interaction: P17252; IntAct: EBI-7206246; Score: 0.27
DE  Interaction: Q92905; IntAct: EBI-2659663; Score: 0.35
DE  Interaction: Q5NI89; IntAct: EBI-2805865; Score: 0.00
DE  Interaction: P31016; IntAct: EBI-7966903; Score: 0.44
DE  Interaction: Q4VCS5; IntAct: EBI-8795849; Score: 0.42
DE  Interaction: Q96S44; IntAct: EBI-6256589; Score: 0.35
DE  Interaction: O14910; IntAct: EBI-6911712; Score: 0.35
DE  Interaction: P46937; IntAct: EBI-6912563; Score: 0.71
DE  Interaction: Q9Y2J4; IntAct: EBI-8795811; Score: 0.35
DE  Interaction: Q7TSJ6; IntAct: EBI-8797641; Score: 0.42
DE  Interaction: O95835; IntAct: EBI-8798552; Score: 0.27
DE  Interaction: Q9H4B6; IntAct: EBI-8799416; Score: 0.27
DE  Interaction: P33215; IntAct: EBI-10993316; Score: 0.35
DE  Interaction: Q96L14; IntAct: EBI-11022408; Score: 0.35
DE  Interaction: P29033; IntAct: EBI-11024719; Score: 0.35
DE  Interaction: E9Q4K7; IntAct: EBI-11042417; Score: 0.35
DE  Interaction: O88952; IntAct: EBI-11079007; Score: 0.35
DE  Interaction: P60006; IntAct: EBI-11091984; Score: 0.35
DE  Interaction: Q8CCJ3; IntAct: EBI-11104920; Score: 0.35
DE  Interaction: Q03933; IntAct: EBI-11107990; Score: 0.35
DE  Interaction: A2APB8; IntAct: EBI-11110977; Score: 0.35
DE  Interaction: Q9R0Q3; IntAct: EBI-11111571; Score: 0.35
DE  Interaction: P37840; IntAct: EBI-11113842; Score: 0.35
DE  Interaction: P04062; IntAct: EBI-11114072; Score: 0.35
DE  Interaction: O75792; IntAct: EBI-11115131; Score: 0.35
DE  Interaction: Q13637; IntAct: EBI-11116348; Score: 0.35
DE  Interaction: O00400; IntAct: EBI-11135399; Score: 0.35
DE  Interaction: P46938; IntAct: EBI-11138299; Score: 0.35
DE  Interaction: Q9Y5I4; IntAct: EBI-21510892; Score: 0.35
DE  Interaction: Q9NUP9; IntAct: EBI-21627409; Score: 0.35
DE  Interaction: Q96A37; IntAct: EBI-21627270; Score: 0.35
DE  Interaction: Q9NSC5; IntAct: EBI-21639932; Score: 0.35
DE  Interaction: Q96NE9; IntAct: EBI-21910666; Score: 0.35
DE  Interaction: Q8NI35; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: Q05639; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: P62873; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: Q9H4B7; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: Q92619; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: Q86YM7; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: P48668; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: P25311; IntAct: EBI-21910914; Score: 0.35
DE  Interaction: Q96QZ7; IntAct: EBI-21911330; Score: 0.35
DE  Interaction: P16104; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q9UNX3; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q9NSB8; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q9HAV0; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q99417; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q96EY4; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q92600; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q8IY63; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: P51572; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: P0C0S5; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q9HAP6; IntAct: EBI-21911017; Score: 0.35
DE  Interaction: Q9C0D5; IntAct: EBI-20732770; Score: 0.44
DE  Interaction: Q99569; IntAct: EBI-20732783; Score: 0.44
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: K9N5R3; IntAct: EBI-26973747; Score: 0.40
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: Q92630; IntAct: EBI-28952196; Score: 0.27
DE  Interaction: Q96ED9; IntAct: EBI-34575530; Score: 0.27
GO  GO:0043296;
GO  GO:0016324;
GO  GO:0005923;
GO  GO:0030054;
GO  GO:0034451;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0070062;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0035089;
GO  GO:0045197;
GO  GO:0035556;
GO  GO:0120192;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:11964389};
SQ  MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRK
SQ  GLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKV
SQ  DIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPET
SQ  VCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSV
SQ  RMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSI
SQ  IPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALF
SQ  LTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYS
SQ  KLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLF
SQ  DDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLV
SQ  ADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTI
SQ  HDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWEMHEFLTPRLQEMDEEREILVDEEYELYQ
SQ  DPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPS
SQ  TEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYA
SQ  TDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALK
SQ  TGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMK
SQ  LPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGR
SQ  MRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSV
SQ  EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEI
SQ  SKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDE
SQ  AHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL
SQ  KCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEIN
SQ  RELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA
SQ  DTNISAIAAQLENMSTGYHLGSPTAEHHPEDTEEQLQMTAD
//