ID  Q8TAG9;
PN  Exocyst complex component 6;
GN  EXOC6;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:O54923}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54923}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54923}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000250|UniProtKB:O54923, ECO:0000269|PubMed:16213214}.
DR  UNIPROT: Q8TAG9;
DR  UNIPROT: E9PHI3;
DR  UNIPROT: Q5VXH8;
DR  UNIPROT: Q9NZ24;
DR  Pfam: PF04091;
DR  OMIM: 609672;
DR  DisGeNET: 54536;
DE  Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: O43542; IntAct: EBI-11129266; Score: 0.35
DE  Interaction: O60645; IntAct: EBI-21673041; Score: 0.51
DE  Interaction: P0DTD1; IntAct: EBI-26951880; Score: 0.49
DE  Interaction: P50148; IntAct: EBI-21673041; Score: 0.35
DE  Interaction: P62834; IntAct: EBI-21673041; Score: 0.35
DE  Interaction: Q53GS7; IntAct: EBI-25859244; Score: 0.56
DE  Interaction: Q8IYI6; IntAct: EBI-12450124; Score: 0.64
DE  Interaction: P02768; IntAct: EBI-1223494; Score: 0.35
DE  Interaction: Q9BQ95; IntAct: EBI-3385759; Score: 0.37
DE  Interaction: P32119; IntAct: EBI-3385854; Score: 0.37
DE  Interaction: Q96JB6; IntAct: EBI-3385849; Score: 0.37
DE  Interaction: Q92947; IntAct: EBI-3385844; Score: 0.37
DE  Interaction: Q9Y3B2; IntAct: EBI-3385839; Score: 0.37
DE  Interaction: P05067; IntAct: EBI-3385834; Score: 0.37
DE  Interaction: P29474; IntAct: EBI-3385829; Score: 0.37
DE  Interaction: Q8TAG9; IntAct: EBI-3385859; Score: 0.37
DE  Interaction: Q9Y2H9; IntAct: EBI-3385991; Score: 0.37
DE  Interaction: P49810; IntAct: EBI-3386181; Score: 0.37
DE  Interaction: Q96A65; IntAct: EBI-10764425; Score: 0.73
DE  Interaction: P0DOE7; IntAct: EBI-11327042; Score: 0.40
DE  Interaction: Q9NV70; IntAct: EBI-12449995; Score: 0.51
DE  Interaction: O00471; IntAct: EBI-12450093; Score: 0.79
DE  Interaction: P61006; IntAct: EBI-12450124; Score: 0.51
DE  Interaction: Q9UPT5; IntAct: EBI-12450124; Score: 0.51
DE  Interaction: Q96KP1; IntAct: EBI-12450124; Score: 0.64
DE  Interaction: Q16891; IntAct: EBI-12450124; Score: 0.51
DE  Interaction: Q9Y2D4; IntAct: EBI-11923380; Score: 0.00
DE  Interaction: P32970; IntAct: EBI-21512742; Score: 0.35
DE  Interaction: P35414; IntAct: EBI-21559824; Score: 0.35
DE  Interaction: P49146; IntAct: EBI-21569349; Score: 0.35
DE  Interaction: Q8N7X8; IntAct: EBI-21585341; Score: 0.35
DE  Interaction: O75558; IntAct: EBI-21632742; Score: 0.35
DE  Interaction: Q96EV8; IntAct: EBI-21651992; Score: 0.35
DE  Interaction: P27930; IntAct: EBI-21662122; Score: 0.35
DE  Interaction: O60939; IntAct: EBI-21671922; Score: 0.35
DE  Interaction: Q96LW7; IntAct: EBI-21673041; Score: 0.35
DE  Interaction: Q5VIR6; IntAct: EBI-21673041; Score: 0.35
DE  Interaction: Q9H410; IntAct: EBI-21673116; Score: 0.35
DE  Interaction: P08173; IntAct: EBI-21707586; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P0DTC5; IntAct: EBI-26495256; Score: 0.35
DE  Interaction: O43572; IntAct: EBI-26451580; Score: 0.35
DE  Interaction: Q7Z699; IntAct: EBI-25932191; Score: 0.56
GO  GO:0005829;
GO  GO:0000145;
GO  GO:0090543;
GO  GO:0030426;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0006887;
GO  GO:0006893;
GO  GO:0006886;
GO  GO:0090148;
GO  GO:0000281;
GO  GO:0006904;
GO  GO:0090522;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAENSESLGTVPEHERILQEIESTDTACVGPTLRSVYDDQPNAHKKFMEKLDACIRNHDKEIEKMCNFHHQGFVDAITEL
SQ  LKVRTDAEKLKVQVTDTNRRFQDAGKEVIVHTEDIIRCRIQQRNITTVVEKLQLCLPVLEMYSKLKEQMSAKRYYSALKT
SQ  MEQLENVYFPWVSQYRFCQLMIENLPKLREDIKEISMSDLKDFLESIRKHSDKIGETAMKQAQHQKTFSVSLQKQNKMKF
SQ  GKNMYINRDRIPEERNETVLKHSLEEEDENEEEILTVQDLVDFSPVYRCLHIYSVLGDEETFENYYRKQRKKQARLVLQP
SQ  QSNMHETVDGYRRYFTQIVGFFVVEDHILHVTQGLVTRAYTDELWNMALSKIIAVLRAHSSYCTDPDLVLELKNLTVIFA
SQ  DTLQGYGFPVNRLFDLLFEIRDQYNETLLKKWAGVFRDIFEEDNYSPIPVVNEEEYKIVISKFPFQDPDLEKQSFPKKFP
SQ  MSQSVPHIYIQVKEFIYASLKFSESLHRSSTEIDDMLRKSTNLLLTRTLSSCLLNLIRKPHIGLTELVQIIINTTHLEQA
SQ  CKYLEDFITNITNISQETVHTTRLYGLSTFKDARHAAEGEIYTKLNQKIDEFVQLADYDWTMSEPDGRASGYLMDLINFL
SQ  RSIFQVFTHLPGKVAQTACMSACQHLSTSLMQMLLDSELKQISMGAVQQFNLDVIQCELFASSEPVPGFQGDTLQLAFID
SQ  LRQLLDLFMVWDWSTYLADYGQPASKYLRVNPNTALTLLEKMKDTSKKNNIFAQFRKNDRDKQKLIETVVKQLRSLVNGM
SQ  SQHM
//