ID  Q8TAQ9;
PN  SUN domain-containing protein 3;
GN  SUN3;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000250|UniProtKB:Q5SS91}. Nucleus inner membrane {ECO:0000305}.
DR  UNIPROT: Q8TAQ9;
DR  UNIPROT: A4D2F3;
DR  UNIPROT: B4DXK1;
DR  UNIPROT: D3DVM3;
DR  UNIPROT: E7EWC8;
DR  UNIPROT: Q4F965;
DR  UNIPROT: Q7Z4U8;
DR  Pfam: PF07738;
DR  PROSITE: PS51469;
DR  OMIM: 618984;
DR  DisGeNET: 256979;
DE  Function: As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette. {ECO:0000250|UniProtKB:Q5SS91}.
DE  Reference Proteome: Yes;
GO  GO:0005639;
GO  GO:0034993;
GO  GO:0005635;
GO  GO:0043495;
GO  GO:0006998;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSGKTKARRAAMFFRRCSEDASGSASGNALLSEDENPDANGVTRSWKIILSTMLTLTFLLVGLLNHQWLKETDVPQKSRQ
SQ  LYAIIAEYGSRLYKYQARLRMPKEQLELLKKESQNLENNFRQILFLIEQIDVLKALLRDMKDGMDNNHNWNTHGDPVEDP
SQ  DHTEEVSNLVNYVLKKLREDQVEMADYALKSAGASIIEAGTSESYKNNKAKLYWHGIGFLNHEMPPDIILQPDVYPGKCW
SQ  AFPGSQGHTLIKLATKIIPTAVTMEHISEKVSPSGNISSAPKEFSVYGITKKCEGEEIFLGQFIYNKTGTTVQTFELQHA
SQ  VSEYLLCVKLNIFSNWGHPKYTCLYRFRVHGTPGKHI
//