ID  Q8TB68;
PN  Proline-rich protein 7;
GN  PRR7;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000269|PubMed:21460222}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0C6T3}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P0C6T3}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21460222}. Synapse {ECO:0000269|PubMed:27458189}. Cell projection, dendrite {ECO:0000269|PubMed:27458189}. Nucleus {ECO:0000269|PubMed:27458189}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). {ECO:0000250|UniProtKB:P0C6T3}.
DR  UNIPROT: Q8TB68;
DR  UNIPROT: Q8WU53;
DR  UNIPROT: Q9BTA7;
DR  OMIM: 618306;
DR  DisGeNET: 80758;
DE  Function: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222). {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q3V0I2, ECO:0000269|PubMed:21460222, ECO:0000269|PubMed:27458189}.
DE  Reference Proteome: Yes;
DE  Interaction: A8K8V0; IntAct: EBI-3925408; Score: 0.37
DE  Interaction: P46934; IntAct: EBI-30833480; Score: 0.44
DE  Interaction: P46937; IntAct: EBI-30847770; Score: 0.44
GO  GO:0070161;
GO  GO:0005829;
GO  GO:0030425;
GO  GO:0098978;
GO  GO:0016021;
GO  GO:0005654;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0098839;
GO  GO:0099092;
GO  GO:0036041;
GO  GO:1990782;
GO  GO:0044877;
GO  GO:0044389;
GO  GO:0002250;
GO  GO:0046632;
GO  GO:0031397;
GO  GO:0043065;
GO  GO:0010942;
GO  GO:2001269;
GO  GO:0099527;
GO  GO:0033077;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPQPPPH
SQ  RSRLEAPAHAHSHPHVHVHPLLHHGPAQPHAHAHPHPHHHALPHPPPTHLSVPPRPWSYPRQAESDMSKPPCYEEAVLMA
SQ  EPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAPPCPALCLQADRGRRVF
SQ  PSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
//