ID  Q8VZG7;
PN  Ribonuclease TUDOR 1;
GN  TSN1;
OS  3702;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:20484005, ECO:0000269|PubMed:25205572, ECO:0000269|PubMed:25736060}. Cytoplasmic granule {ECO:0000269|PubMed:25205572, ECO:0000269|PubMed:25736060}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20484005}. Endoplasmic reticulum {ECO:0000269|PubMed:20484005}. Note=Accumulates heterogeneously in the cytosol, in patches around the nucleus and in the cell periphery, and relocates transiently to a diffuse pattern in response to salt stress (PubMed:20484005). Accumulates in cytoplasmic stress granules (SGs) and processing bodies (PBs) in response to abiotic stresses (e.g. salt and heat) (PubMed:25205572, PubMed:25736060). {ECO:0000269|PubMed:20484005, ECO:0000269|PubMed:25205572, ECO:0000269|PubMed:25736060}.
DR  UNIPROT: Q8VZG7;
DR  UNIPROT: F4K6N0;
DR  UNIPROT: Q9LY25;
DR  Pfam: PF00565;
DR  Pfam: PF00567;
DR  PROSITE: PS50830;
DR  PROSITE: PS50304;
DE  Function: Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress (PubMed:25736060). Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat) (PubMed:25736060). Involved in gibberellic acid (GA) biosynthesis (PubMed:25205572). Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway (PubMed:20484005). Component of stress granules (SGs) that regulates growth under salt stress by modulating levels of GA20OX3 mRNA. Binds GA20OX3 mRNA (PubMed:25205572). May inhibit the degradation of mRNAs involved in stress adaptation (PubMed:26237081). {ECO:0000269|PubMed:20484005, ECO:0000269|PubMed:25205572, ECO:0000269|PubMed:25736060, ECO:0000269|PubMed:26237081}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9LV27; IntAct: EBI-21137684; Score: 0.35
GO  GO:0005737;
GO  GO:0010494;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0000932;
GO  GO:0048471;
GO  GO:0009505;
GO  GO:0005886;
GO  GO:0016442;
GO  GO:0003729;
GO  GO:0004518;
GO  GO:0003723;
GO  GO:0034605;
GO  GO:0031047;
GO  GO:0006402;
GO  GO:0006397;
GO  GO:0010372;
GO  GO:0009651;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MATGAENQWLKGRVKAVTSGDCLVITALSHNRAGPPPEKTITFSSLMAPKMARRGGIDEPFAWESKEFLRKLCIGKEVAF
SQ  KVDYKVEAIAGREFGSVFLGNENLAKLVVKTGWAKVREPGQQNQDKVSPYIKELLQLEELAKQEGYGRWSKVPGAAEASI
SQ  RNLPPSAIGDSAGFDAMGLLAANKGKPMEGIVEQVRDGSTIRVYLLPEFQFVQVFVAGVQAPSMGRRTTNGSVVETVPDE
SQ  PNGDVSAESRGPLTTAQRLAASAASSVEVSSDPFATEAKYFTEHRVLSRDVRIVLEGVDKFNNLIGSVHYSDGETVKDLG
SQ  LELVENGLAKFVEWSANMMEEEAKKKLKAAELQCKKDKVKMWANYVPPATNSKAIHDQNFTGKVVEVVSGDCLIVADDAV
SQ  PFGSPAAERRVCLSSIRSPKMGNPRREEKPAPYAREAREFLRQRLIGKQVIVQMEYSRKVTQGDGPTTSGAADRFMDFGS
SQ  VFLPSAAKADSDEVTAPPAAAIAGSQPVGVNIAELVLVRGFGNVVRHRDFEERSNHYDALLAAEARALAGKKGIHSAKES
SQ  PAMHITDLTVSAAKKAKDFLPSLQRIRRIPAVVEYVLSGHRFKLYIPKITCSIAFSFSGVRCPGRGEPYSEEAISVMRRR
SQ  IMQRDVEIEVETVDRTGTFLGSMWESRTNVATVLLEAGLAKMQTSFGADRIAEAHLLEQAERSAKNQKLKIWENYVEGEE
SQ  VSNGNTNTVETRQKETLKVVVTEVLGGGRFYVQSAGDQKIASIQNQLASLSIKDAPIIGSFNPKRGDIVLAQFSLDNSWN
SQ  RAMIVTAPRAAVQSPDEKFEVFYIDYGNQETVPYSAIRPIDPSVSAAPGLAQLCRLAYIKVPSLEDDFGPEAGEYLHTVT
SQ  LGSGKEFKAVIEERDTSGGKVKGQGTGTEFVVTLIAVDDEISVNAAMLQEGIARMEKRQKWGHKGKQAALDALEKFQEEA
SQ  RKSRIGIWQYGDIESDDEDTGPARKPAGGRR
//