ID  Q8WTR4;
PN  Glycerophosphodiester phosphodiesterase domain-containing protein 5;
GN  GDPD5;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Endomembrane system {ECO:0000250|UniProtKB:Q640M6}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q640M6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q640M6}. Note=In a punctate perinuclear pattern. {ECO:0000250|UniProtKB:Q640M6}.
DR  UNIPROT: Q8WTR4;
DR  UNIPROT: Q49AQ5;
DR  UNIPROT: Q6UX76;
DR  UNIPROT: Q7Z4S0;
DR  UNIPROT: Q8N781;
DR  UNIPROT: Q8NCB7;
DR  UNIPROT: Q8TB77;
DR  Pfam: PF03009;
DR  PROSITE: PS51704;
DR  OMIM: 609632;
DR  DisGeNET: 81544;
DE  Function: Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q3KTM2, ECO:0000250|UniProtKB:Q640M6}.
DE  Reference Proteome: Yes;
DE  Interaction: O75844; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q14677; IntAct: EBI-16430940; Score: 0.56
DE  Interaction: Q8NC56; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q81WF2; IntAct: EBI-2833213; Score: 0.00
DE  Interaction: P50542; IntAct: EBI-10276098; Score: 0.56
DE  Interaction: Q8IUQ4; IntAct: EBI-10276108; Score: 0.56
DE  Interaction: Q70JA7; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9Y6N7; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9Y6I9; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9Y397; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9UNK0; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9UI09; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9UEU0; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9NV66; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9NUE0; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9NQ84; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9BX95; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9BWL3; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9BTX1; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9BRX8; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q9BRB3; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q969P0; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q969E2; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q92838; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q8WUY1; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q8N4L2; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q6UW68; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q6NUM9; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q5VT66; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q14654; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: P62341; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: P43304; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: O75380; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: O43306; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: O43181; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: O15400; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: O00461; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: P0CG08; IntAct: EBI-21566764; Score: 0.35
DE  Interaction: Q6PEX3; IntAct: EBI-22134456; Score: 0.37
GO  GO:0012505;
GO  GO:0030426;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0047389;
GO  GO:0008889;
GO  GO:0004435;
GO  GO:0006629;
GO  GO:0007399;
GO  GO:0045666;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWYLYNRM
SQ  GYWSDWPVPILVTTAAAFAYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGT
SQ  APFLHVGAVAAVTMLSWIVAGQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLA
SQ  PEHTLMSFRKALEQKLYGLQADITISLDGVPFLMHDTTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPF
SQ  WTASSLSPSDHREAQNQSICSLAELLELAKGNATLLLNLRDPPREHPYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPL
SQ  VRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQVSRQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHA
SQ  LSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISD
SQ  GVEVSDVLSVCSDNSYDTYANSTATPVGPRGGGSHTKTLIERSGR
//