ID  Q8WUX9;
PN  Charged multivesicular body protein 7;
GN  CHMP7;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:16856878}. Nucleus envelope {ECO:0000269|PubMed:26040712}. Nucleus envelope {ECO:0000269|PubMed:28242692}. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area (PubMed:16856878). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (PubMed:26040712, PubMed:28242692). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
DR  UNIPROT: Q8WUX9;
DR  UNIPROT: B2RDT3;
DR  UNIPROT: B4DKJ6;
DR  UNIPROT: D3DSS1;
DR  UNIPROT: Q8NDM1;
DR  UNIPROT: Q9BT50;
DR  Pfam: PF03357;
DR  OMIM: 611130;
DE  Function: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:28242692, PubMed:26040712). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}.
DE  Reference Proteome: Yes;
DE  Interaction: P01112; IntAct: EBI-25869447; Score: 0.66
DE  Interaction: P62826; IntAct: EBI-25890253; Score: 0.56
DE  Interaction: Q15102; IntAct: EBI-757165; Score: 0.55
DE  Interaction: Q96GX1; IntAct: EBI-11394923; Score: 0.27
DE  Interaction: Q6P5F9; IntAct: EBI-11603310; Score: 0.35
DE  Interaction: Q9H444; IntAct: EBI-11513083; Score: 0.54
DE  Interaction: Q9BY43; IntAct: EBI-11513112; Score: 0.37
DE  Interaction: Q96CF2; IntAct: EBI-11513134; Score: 0.37
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.27
DE  Interaction: Q9BYV6; IntAct: EBI-22022524; Score: 0.00
DE  Interaction: P55212; IntAct: EBI-25835897; Score: 0.56
DE  Interaction: P06307; IntAct: EBI-25837149; Score: 0.56
DE  Interaction: P28329; IntAct: EBI-25838258; Score: 0.56
DE  Interaction: G5E9A7; IntAct: EBI-25843392; Score: 0.56
DE  Interaction: P22607; IntAct: EBI-25855156; Score: 0.56
DE  Interaction: Q0VDC6; IntAct: EBI-25856156; Score: 0.56
DE  Interaction: Q14957; IntAct: EBI-25863073; Score: 0.56
DE  Interaction: P06396; IntAct: EBI-25864746; Score: 0.56
DE  Interaction: P54652; IntAct: EBI-25870109; Score: 0.56
DE  Interaction: P13473; IntAct: EBI-25874252; Score: 0.56
DE  Interaction: D3DTS7; IntAct: EBI-25883702; Score: 0.56
DE  Interaction: O14645; IntAct: EBI-25903256; Score: 0.56
DE  Interaction: O14901; IntAct: EBI-25906055; Score: 0.56
DE  Interaction: Q9BVL2; IntAct: EBI-25908519; Score: 0.56
DE  Interaction: Q9UMX0; IntAct: EBI-25921437; Score: 0.56
DE  Interaction: Q7Z699; IntAct: EBI-25933071; Score: 0.56
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: P07949; IntAct: EBI-32725031; Score: 0.27
GO  GO:1904930;
GO  GO:0000421;
GO  GO:0005829;
GO  GO:0000815;
GO  GO:0000776;
GO  GO:0005828;
GO  GO:0005765;
GO  GO:0030496;
GO  GO:0005771;
GO  GO:0032585;
GO  GO:0005635;
GO  GO:0005643;
GO  GO:0005654;
GO  GO:0005886;
GO  GO:0097352;
GO  GO:0006914;
GO  GO:1904903;
GO  GO:0010458;
GO  GO:1902774;
GO  GO:0045324;
GO  GO:0032511;
GO  GO:0090148;
GO  GO:0061952;
GO  GO:0007080;
GO  GO:0036258;
GO  GO:0071985;
GO  GO:0061763;
GO  GO:0060548;
GO  GO:0031468;
GO  GO:0006997;
GO  GO:0001778;
GO  GO:0071168;
GO  GO:0015031;
GO  GO:1901673;
GO  GO:0043162;
GO  GO:0006900;
GO  GO:0051469;
GO  GO:0046761;
GO  GO:0039702;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MWSPEREAEAPAGGDPAGLLPPEWEEDEERMSFLFSAFKRSREVNSTDWDSKMGFWAPLVLSHSRRQGVVRLRLRDLQEA
SQ  FQRKGSVPLGLATVLQDLLRRGELQRESDFMASVDSSWISWGVGVFLLKPLKWTLSNMLGDNKVPAEEVLVAVELLKEKA
SQ  EEVYRLYQNSPLSSHPVVALSELSTLCANSCPDERTFYLVLLQLQKEKRVTVLEQNGEKIVKFARGPRAKVSPVNDVDVG
SQ  VYQLMQSEQLLSRKVESLSQEAERCKEEARRACRAGKKQLALRSLKAKQRTEKRIEALHAKLDTVQGILDRIYASQTDQM
SQ  VFNAYQAGVGALKLSMKDVTVEKAESLVDQIQELCDTQDEVSQTLAGGVTNGLDFDSEELEKELDILLQDTTKEPLDLPD
SQ  NPRNRHFTNSVPNPRISDAELEAELEKLSLSEGGLVPSSKSPKRQLEPTLKPL
//