ID  Q8WY41;
PN  Nanos homolog 1;
GN  NANOS1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Cytoplasm {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:19168546}. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:19168546}.
DR  UNIPROT: Q8WY41;
DR  PDB: 4CQO;
DR  Pfam: PF05741;
DR  PROSITE: PS51522;
DR  OMIM: 608226;
DR  OMIM: 615413;
DR  DisGeNET: 340719;
DE  Function: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.
DE  Disease: Spermatogenic failure 12 (SPGF12) [MIM:615413]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Non-obstructive azoospermia, oligozoospermia and oligo-astheno- teratozoospermia are features observed in SPGF12 patients. {ECO:0000269|PubMed:23315541}. Note=The disease is caused by variants affecting the gene represented in this entry.
DE  Reference Proteome: Yes;
DE  Interaction: O60716; IntAct: EBI-9639078; Score: 0.52
GO  GO:0005737;
GO  GO:0048471;
GO  GO:0003729;
GO  GO:0030371;
GO  GO:0008270;
GO  GO:0016477;
GO  GO:0098749;
GO  GO:0010631;
GO  GO:0017148;
GO  GO:0048477;
GO  GO:1900153;
GO  GO:0010608;
GO  GO:0001558;
GO  GO:0001894;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEAFPWAPRSPRRGRAPPPMALVPSARYVSAPGPAHPQPFSSWNDYLGLATLITKAVDGEPRFGCARGGNGGGGSPPSSS
SQ  SSSCCSPHTGAGPGALGPALGPPDYDEDDDDDSDEPGSRGRYLGSALELRALELCAGPAEAGLLEERFAELSPFAGRAAA
SQ  VLLGCAPAAAAAATTTSEATPREERAPAWAAEPRLHAASGAAAARLLKPELQVCVFCRNNKEAMALYTTHILKGPDGRVL
SQ  CPVLRRYTCPLCGASGDNAHTIKYCPLSKVPPPPARPPPRSARDGPPGKKLR
//