ID  Q90972;
PN  E3 ubiquitin-protein ligase RNF13;
GN  RNF13;
OS  9031;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000305|PubMed:8610176}; Single-pass type I membrane protein {ECO:0000255}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250|UniProtKB:O54965}.
DR  UNIPROT: Q90972;
DR  UNIPROT: Q533M4;
DR  Pfam: PF02225;
DR  Pfam: PF13639;
DR  PROSITE: PS50089;
DE  Function: E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:20015074). Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity). {ECO:0000250|UniProtKB:O43567, ECO:0000269|PubMed:20015074}.
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0031902;
GO  GO:0005765;
GO  GO:0005654;
GO  GO:0008432;
GO  GO:0046872;
GO  GO:0061630;
GO  GO:0004842;
GO  GO:0051640;
GO  GO:0070304;
GO  GO:0051865;
GO  GO:0006511;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLLSIGMLMLSATQIYTIVTVQLFAFLNLLPVEADILAYNFENGTQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPI
SQ  APPPLRDNSSTAFIVLIRRLECNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEILKKIDIPSVFIGEASANSLKE
SQ  EFTYEKGGHVVLIPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVC
SQ  AICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSETDSSQEENEVSENTPLLRPLASVST
SQ  QSFGALSESHSHQNMTESSEYEEDDNDNIDSSDAESGVNEESVVVQLQPNDERDYRVTNTV
//