ID  Q90YM8;
PN  Cytoplasmic FMR1-interacting protein 1 homolog;
GN  cyfip1;
OS  7955;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:Q7TMB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q7TMB8}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TMB8}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q7TMB8}. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250|UniProtKB:Q7TMB8}.
DR  UNIPROT: Q90YM8;
DR  UNIPROT: Q58ES3;
DR  Pfam: PF07159;
DR  Pfam: PF05994;
DE  Function: Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA (By similarity). {ECO:0000250|UniProtKB:Q7L576, ECO:0000250|UniProtKB:Q7TMB8}.
DE  Reference Proteome: Yes;
GO  GO:0070161;
GO  GO:0005737;
GO  GO:0030027;
GO  GO:0043005;
GO  GO:0048471;
GO  GO:0001726;
GO  GO:0031209;
GO  GO:0045202;
GO  GO:0051015;
GO  GO:0000340;
GO  GO:0031267;
GO  GO:0048675;
GO  GO:0007411;
GO  GO:0000902;
GO  GO:0030031;
GO  GO:0030032;
GO  GO:0099563;
GO  GO:0030833;
GO  GO:0008360;
GO  GO:0006417;
GO  GO:0031529;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MASTVTLEDALSNVDLLEELPLPDQQPCIEPLPSSLIYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNDMLEEGQQYA
SQ  VMLYTWRCCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVNKLMNFMYFQRTAIDRFCGEVRRLCHAERRKDFVSEAYLLT
SQ  LGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMSEPSSIQESQNLSMFLANHNKITQSLQQQLEVINGYDELLAD
SQ  IVNLCVDYYENKMYLTPSERHMLLKVMGFGLYLMDGSNSNIYKLEAKKRINLTKIDKFFKQLQVVPLFGDMQIELARYIK
SQ  TSAHYEENKSRWSCTSTGSSPQYNVCEQMIQIREGHMRFISELARYSNSEVVTGSGRQDAQKTDSEYRKLFDLALQGLQL
SQ  LSQWSAQIMEVYSWKLVHPTDKYSNKECPDNAEEYERATRYNYTSEEKFALVEVLAMIKGLQVLMGRMESVFNHAIRHTI
SQ  YSALQDFAQVTLREPLRQAIKKKKNVVQSVLQAIRKTVCDWETGREPHNDPALRGEKDPKGGFDIKVPRRAVGPSSTQLY
SQ  MVRTMLESLVADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLLNFSETLQQCCDLSQLWFREFFLELTMGRRIQFPI
SQ  EMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVIAGS
SQ  LLLDKRLRAECKNQGANISWPSSNRYETLLKQRHVQLLGRSIDLNRLITQRVSSALYKSLELAISRFESEDLTSIMELEG
SQ  LLDINRMTHKLLSKYLTLDSIDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTILPFSQEFQRDKP
SQ  PNAQPQYLYGSKALNLAYSSIYSLYRNFVGPPHIKAICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKIC
SQ  RLPRHEYGSPGILEFFHHQLKDIVEYAELKSVCFQNLREVGNALLFCLLTEQSLSQEEVCDLLHAAPFQNILPRVHVKEG
SQ  ERLDAKMKRLEAKYTALHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSIFEVILTRVRAYLDDPIWRGPLPSNGVMH
SQ  VDECVEFHRLWSAMQFVYCIPVGAHEFTVEQCFGDGLNWAGCMIITLLGQHRRFDILDFSYHLLKVQKHDGKDEIIKSVP
SQ  LKKMVDRIRKFQILNDEIFAILNKYLKSGDGENMPVEHVRCFQPPIHQSLASN
//