ID  Q90Z16;
PN  Optineurin;
GN  OPTN;
OS  9031;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:11777338, ECO:0000269|PubMed:12169269}. Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:12169269}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Recycling endosome {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}.
DR  UNIPROT: Q90Z16;
DR  Pfam: PF16516;
DR  Pfam: PF11577;
DR  PROSITE: PS51801;
DE  Function: Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. {ECO:0000269|PubMed:11777338, ECO:0000269|PubMed:12169269}.
DE  Reference Proteome: Yes;
GO  GO:0005776;
GO  GO:0005737;
GO  GO:0005794;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0055037;
GO  GO:0070530;
GO  GO:0046872;
GO  GO:0006914;
GO  GO:0090161;
GO  GO:0034067;
GO  GO:0043122;
GO  GO:0016192;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSSKPQIRPAENGEHCRSKMENGMDSMAPPTLSTYTPEEMVQQMKELITENNELKEAMKLHNQAMKDRYEELSIWREKQK
SQ  EEREFYETKFKEAKQCLLAKCVENEQLQQQLQSLKEREEGAEMEGCATPEKEARQLKSKVQRLQAEKADLLAIISELQVK
SQ  LNIASAEDSFVEIGMNEEVNRTARENQDNSSEMASNIAVYIRSKSADESKNLESEELTVSQLLCCLRNETQRREKLEKEL
SQ  QDHKERLSKMENETSNCLESGTQTNQEEESSEAIGSEVESLKKQICALFKELQEAHEKLKEAELIQKKLQEKCQTLEKVN
SQ  SAAATELEEKQQLIYTIKKLELQVESVQAEVKLEQAKTQDEKTRYSSLQDAYNKLLAELTEAMKTISEMKVKEHDRVDKV
SQ  VVEELNAKVLLAEQALAAKQLQMDEMKQLIAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLAVQLAYLLK
SQ  EQQNLEDLGRSSLAEMQNRHGARAPDREHSPRLVQRGTGSQEWPEQRNISIYSCPKCEEILPDLDTLQIHVMDCIN
//