ID  Q91836;
PN  Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog B;
GN  prkra;
OS  8355;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000269|PubMed:9230068}. Nucleus, nucleolus {ECO:0000269|PubMed:9230068}.
DR  UNIPROT: Q91836;
DR  PDB: 1DI2;
DR  Pfam: PF00035;
DR  Pfam: PF16482;
DR  PROSITE: PS50137;
DE  Function: Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005730;
GO  GO:0048471;
GO  GO:0003725;
GO  GO:0008047;
GO  GO:0030422;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSSEKPTSLNAMRATNPCETPIQLLHEFGTKTGNHPVYTLEKAEGQAHNPSFTFRLVIGDITSLGEGPSKKTPKQKAAEF
SQ  ALNILRGDTSKCLPVTDTLRDPKKPPNQMQENPVGSLQELAVQKGWRLPEYTVAQESGPPHKREFTITCRVETFVETGSG
SQ  TSKQVAKRVAAEKLLTKFKTISTDNIPLNKLIGNKMGCTWDSMRNSSGEKISMLKRSPLSIPNTDYVKMLKDVAEELDFN
SQ  LTYLDIDELSVNGQYQCLAELSTNPITVCHGTGISCGNAHNDAAHNALQYLKIMCIKK
//