ID  Q921C5;
PN  Protein bicaudal D homolog 2;
GN  Bicd2;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Golgi apparatus {ECO:0000269|PubMed:11483508, ECO:0000269|PubMed:12447383, ECO:0000269|PubMed:25962623}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11483508}. Cytoplasm {ECO:0000250|UniProtKB:Q8TD16}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8TD16}. Nucleus envelope {ECO:0000250|UniProtKB:Q8TD16}. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (PubMed:11483508). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (By similarity). {ECO:0000250|UniProtKB:Q8TD16, ECO:0000269|PubMed:11483508}.
DR  UNIPROT: Q921C5;
DR  UNIPROT: Q80TU1;
DR  UNIPROT: Q8BTE3;
DR  UNIPROT: Q9DCL3;
DR  Pfam: PF09730;
DE  Function: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:11483508, PubMed:25035494, PubMed:24986880, PubMed:22956769). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form (PubMed:25962623). Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:12447383, PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (PubMed:20386726). {ECO:0000269|PubMed:11483508, ECO:0000269|PubMed:12447383, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:22956769, ECO:0000269|PubMed:24986880, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:25962623}.
DE  Reference Proteome: Yes;
DE  Interaction: P46060; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: P49792; IntAct: EBI-15847872; Score: 0.63
DE  Interaction: Q12840; IntAct: EBI-15847851; Score: 0.41
DE  Interaction: Q14203; IntAct: EBI-7894652; Score: 0.35
DE  Interaction: Q8N1F7; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: Q9JL25; IntAct: EBI-650530; Score: 0.37
DE  Interaction: P35279; IntAct: EBI-7893837; Score: 0.51
DE  Interaction: O14576; IntAct: EBI-7894652; Score: 0.35
DE  Interaction: Q8VHQ4; IntAct: EBI-11569919; Score: 0.35
DE  Interaction: Q5SW79; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: O60447; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: O75122; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: O60333; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: P35579; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: O00159; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: Q86SQ0; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: O43896; IntAct: EBI-15847893; Score: 0.35
DE  Interaction: P20340; IntAct: EBI-15847968; Score: 0.41
DE  Interaction: Q8BUK6; IntAct: EBI-25297227; Score: 0.36
GO  GO:0005642;
GO  GO:0005813;
GO  GO:0005737;
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0005635;
GO  GO:0005643;
GO  GO:0005886;
GO  GO:0008093;
GO  GO:0034452;
GO  GO:0070840;
GO  GO:0051959;
GO  GO:0031267;
GO  GO:0051642;
GO  GO:0072393;
GO  GO:0007018;
GO  GO:0072385;
GO  GO:0051028;
GO  GO:0034067;
GO  GO:0033365;
GO  GO:0015031;
GO  GO:0070507;
GO  GO:0006890;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKE
SQ  AFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKEINQNVEIQR
SQ  GRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQL
SQ  EEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDTVTAEPNNDAEALVNGFEHSGLVKSSLDNKTS
SQ  TPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALR
SQ  RLQAGKERQTSLDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEG
SQ  QALTEKISLLEKASHQDRELLAHLEKELKKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYR
SQ  EGQGKAGRTSPEGRGRRSPVLLPKGLLATEVGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAA
SQ  VDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTE
SQ  TMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHE
SQ  QTRRGRSKAASKAKPASPSL
//