ID  Q921T2;
PN  Torsin-1A-interacting protein 1;
GN  Tor1aip1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
DR  UNIPROT: Q921T2;
DR  UNIPROT: E9QLK1;
DR  UNIPROT: Q1EQW1;
DR  UNIPROT: Q3U7A4;
DR  Pfam: PF05609;
DE  Function: Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. {ECO:0000269|PubMed:20457914}.
DE  Reference Proteome: Yes;
DE  Interaction: Q5JTV8; IntAct: EBI-2559664; Score: 0.40
DE  Interaction: Q7L576; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: P27824; IntAct: EBI-2559664; Score: 0.56
DE  Interaction: Q8TCX1; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: D6RA89; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: P50416; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q9UBD5; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: I3L1P8; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q13867; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: O60292; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: P52789; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q9Y6K0; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q5K651; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q15758; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: P0C0L5; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q9Y2H6; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: O00461; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: O14925; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q9BUK6; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: O94822; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: J3QLU9; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: H7C2E6; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: O14828; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q06830; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q5XPI4; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q9BX66; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q9HBH0; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q5VYS8; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q10471; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: P50570; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: O95149; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: O00231; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: P51532; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: P32119; IntAct: EBI-10996616; Score: 0.35
DE  Interaction: Q99ME6; IntAct: EBI-15644413; Score: 0.37
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0001671;
GO  GO:0051117;
GO  GO:0008092;
GO  GO:0005521;
GO  GO:0061024;
GO  GO:0071763;
GO  GO:0032781;
GO  GO:0090435;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAGERWQAEGPGEGWAIYVTPRAPIREGRRRLDPRNGDSSDAPAYGAHPSRRGRREVRFSEEPAEVYGDFEPRAAKERSP
SQ  GGRRTPPEKFRPASAGEEVRESAYNLRSRPRRQRRAQEAEEMKTRRSARLEQHSQQPQLSPATSGRGLRDSPSSSEDREE
SQ  DEPSSRPVTSQTASKKTLRTPEASVMNEDPISNLCRPPLRSPRLDSTYQTNGNTKTNEREATIVQQVNFFEEGETEDDLE
SQ  SSYSDITIRARSSDSLESRDEATPAAGNHPDSLRGLPHNQDFPAHENQPLLLTSGCQENPQEWVDRAVRMRSRMAYNNIQ
SQ  KSNFGNQSPSTSRPQSAIHHPNEPSVKIKWWLLGLVAILAVGLFWFFHTPAVETTAVQEFQNQMKQLQSKYQSQNEKLWK
SQ  RGTTFLEKHLNSSLPRPQPAILLLTAAQDAAEVLKCLSEQIADAYSSFRSVRAIRIDGAGKAAQDSDLVKHEVDQELTDG
SQ  FKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEKTLEASLGLKEIEEKVRDFLKVKFTSSSTASS
SQ  YNHMDPDKLNGLWSRISHLVLPVQPENTLKAGSCL
//