ID  Q92575;
PN  UBX domain-containing protein 4;
GN  UBXN4;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16968747}; Peripheral membrane protein {ECO:0000269|PubMed:16968747}. Nucleus envelope {ECO:0000269|PubMed:16968747}. Note=Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. {ECO:0000269|PubMed:16968747}.
DR  UNIPROT: Q92575;
DR  UNIPROT: A8K9W4;
DR  UNIPROT: Q4ZG56;
DR  UNIPROT: Q8IYM5;
DR  PDB: 2KXJ;
DR  Pfam: PF00789;
DR  PROSITE: PS50033;
DR  OMIM: 611216;
DR  DisGeNET: 23190;
DE  Function: Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669). {ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}.
DE  Reference Proteome: Yes;
DE  Interaction: P01112; IntAct: EBI-27045317; Score: 0.27
DE  Interaction: O75674; IntAct: EBI-736145; Score: 0.00
DE  Interaction: P55072; IntAct: EBI-1996648; Score: 0.67
DE  Interaction: P17028; IntAct: EBI-2682714; Score: 0.00
DE  Interaction: Q5NEU6; IntAct: EBI-2799980; Score: 0.00
DE  Interaction: Q5NIJ3; IntAct: EBI-2799973; Score: 0.00
DE  Interaction: Q9UMX0; IntAct: EBI-10278693; Score: 0.72
DE  Interaction: Q5HYA8; IntAct: EBI-11367583; Score: 0.27
DE  Interaction: Q6NUS6; IntAct: EBI-11368748; Score: 0.27
DE  Interaction: Q86UK5; IntAct: EBI-11372136; Score: 0.27
DE  Interaction: Q86X19; IntAct: EBI-11372615; Score: 0.27
DE  Interaction: Q96GX1; IntAct: EBI-11375285; Score: 0.27
DE  Interaction: Q9P0N5; IntAct: EBI-11378021; Score: 0.27
DE  Interaction: P63211; IntAct: EBI-24802515; Score: 0.56
DE  Interaction: P21802; IntAct: EBI-21718282; Score: 0.35
DE  Interaction: Q9H165; IntAct: EBI-21885450; Score: 0.35
DE  Interaction: Q96RL7; IntAct: EBI-21885450; Score: 0.35
DE  Interaction: Q92551; IntAct: EBI-21885450; Score: 0.35
DE  Interaction: Q709C8; IntAct: EBI-21885450; Score: 0.35
DE  Interaction: Q6V1X1; IntAct: EBI-21885450; Score: 0.35
DE  Interaction: Q14139; IntAct: EBI-25771321; Score: 0.50
DE  Interaction: P27824; IntAct: EBI-16788621; Score: 0.27
DE  Interaction: O14880; IntAct: EBI-16796348; Score: 0.27
DE  Interaction: Q9HBL7; IntAct: EBI-16797780; Score: 0.27
DE  Interaction: Q15388; IntAct: EBI-16801791; Score: 0.27
DE  Interaction: Q9NS69; IntAct: EBI-16802054; Score: 0.27
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: Q9GZP9; IntAct: EBI-25770670; Score: 0.35
DE  Interaction: P01116; IntAct: EBI-27041844; Score: 0.27
DE  Interaction: P01111; IntAct: EBI-27042293; Score: 0.27
DE  Interaction: A0A0H3NF08; IntAct: EBI-27055973; Score: 0.27
DE  Interaction: A0A0H3NB75; IntAct: EBI-27055983; Score: 0.27
DE  Interaction: P56180; IntAct: EBI-27116883; Score: 0.27
DE  Interaction: Q9H492; IntAct: EBI-30829630; Score: 0.44
DE  Interaction: Q9GZQ8; IntAct: EBI-30831343; Score: 0.44
DE  Interaction: P08069; IntAct: EBI-32722947; Score: 0.27
DE  Interaction: P06213; IntAct: EBI-32723092; Score: 0.27
DE  Interaction: Q5W0V3; IntAct: EBI-34574999; Score: 0.27
DE  Interaction: Q86V87; IntAct: EBI-34575191; Score: 0.27
GO  GO:0005829;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0005635;
GO  GO:0006986;
GO  GO:0030433;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:16968747};
SQ  MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSS
SQ  FFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPT
SQ  SDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKR
SQ  KQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVA
SQ  RIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPT
SQ  ASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKK
SQ  EGKIYRLRTQDDGEDENNTWNGNSTQQM
//