ID  Q925U2;
PN  Leukotriene C4 synthase;
GN  Ltc4s;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Comments: Nucleus outer membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}. Nucleus membrane {ECO:0000250|UniProtKB:Q16873}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16873}.
DR  UNIPROT: Q925U2;
DR  UNIPROT: G3V6E6;
DR  Pfam: PF01124;
DR  PROSITE: PS01297;
DE  Function: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:12445492). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (By similarity). {ECO:0000250|UniProtKB:Q16873, ECO:0000269|PubMed:12445492}.
DE  Reference Proteome: Yes;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0043231;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005640;
GO  GO:0008047;
GO  GO:0043295;
GO  GO:0004602;
GO  GO:0004364;
GO  GO:0042802;
GO  GO:0004464;
GO  GO:0008289;
GO  GO:0044877;
GO  GO:0071222;
GO  GO:0071299;
GO  GO:0019370;
GO  GO:0006691;
GO  GO:0042759;
GO  GO:0048678;
GO  GO:0010035;
GO  GO:0032496;
GO  GO:0009410;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q16873};
SQ  MKEETALLATVTLLGVLLQAYFSLQVISARRTFHVSPPLTSGPPEFERVFRAQVNCSEYFPLFLATLWVAGIFFHEGAAA
SQ  LCGLFYLFARLRYFQGYARSAQHRLDPLYASARALWLLVAMAALGLLVHFLPGTLRAALFRWLQVLLPMA
//