ID  Q93084;
PN  Sarcoplasmic/endoplasmic reticulum calcium ATPase 3;
GN  ATP2A3;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}.
DR  UNIPROT: Q93084;
DR  UNIPROT: A8MZG0;
DR  UNIPROT: D3DTJ8;
DR  UNIPROT: O60900;
DR  UNIPROT: O60901;
DR  UNIPROT: O75501;
DR  UNIPROT: O75502;
DR  UNIPROT: Q16115;
DR  UNIPROT: Q6JHX1;
DR  UNIPROT: Q8TEX5;
DR  UNIPROT: Q8TEX6;
DR  Pfam: PF00689;
DR  Pfam: PF00690;
DR  PROSITE: PS00154;
DR  OMIM: 601929;
DR  DisGeNET: 489;
DE  Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
DE  Reference Proteome: Yes;
DE  Interaction: P04626; IntAct: EBI-8770853; Score: 0.35
DE  Interaction: P0DTD1; IntAct: EBI-26496082; Score: 0.35
DE  Interaction: Q9HAW0; IntAct: EBI-1064949; Score: 0.00
DE  Interaction: Q9P2S5; IntAct: EBI-1079489; Score: 0.00
DE  Interaction: P04439; IntAct: EBI-1079517; Score: 0.00
DE  Interaction: P13569; IntAct: EBI-1171098; Score: 0.35
DE  Interaction: P16333; IntAct: EBI-1967197; Score: 0.40
DE  Interaction: P15336; IntAct: EBI-5529812; Score: 0.35
DE  Interaction: P04578; IntAct: EBI-6177436; Score: 0.35
DE  Interaction: Q96DB2; IntAct: EBI-6598272; Score: 0.35
DE  Interaction: Q20MH8; IntAct: EBI-12586007; Score: 0.35
DE  Interaction: P22460; IntAct: EBI-21505491; Score: 0.35
DE  Interaction: Q86UE6; IntAct: EBI-21507777; Score: 0.35
DE  Interaction: Q9UN75; IntAct: EBI-21537575; Score: 0.35
DE  Interaction: Q7KYR7; IntAct: EBI-21541130; Score: 0.35
DE  Interaction: Q2Y0W8; IntAct: EBI-21566582; Score: 0.35
DE  Interaction: Q9C099; IntAct: EBI-21571999; Score: 0.35
DE  Interaction: Q6UXE8; IntAct: EBI-21583647; Score: 0.35
DE  Interaction: Q9UN71; IntAct: EBI-21584146; Score: 0.35
DE  Interaction: O43291; IntAct: EBI-21587968; Score: 0.35
DE  Interaction: Q8TDD5; IntAct: EBI-21589012; Score: 0.35
DE  Interaction: Q8WW62; IntAct: EBI-21589315; Score: 0.35
DE  Interaction: P58658; IntAct: EBI-21588759; Score: 0.35
DE  Interaction: Q9BQ31; IntAct: EBI-21590203; Score: 0.35
DE  Interaction: Q96FT7; IntAct: EBI-21589962; Score: 0.35
DE  Interaction: Q9NRJ7; IntAct: EBI-21590428; Score: 0.35
DE  Interaction: Q96FV3; IntAct: EBI-21591007; Score: 0.35
DE  Interaction: Q9Y5M8; IntAct: EBI-21633655; Score: 0.35
DE  Interaction: Q9Y5F2; IntAct: EBI-21658599; Score: 0.35
DE  Interaction: Q16281; IntAct: EBI-21687526; Score: 0.35
DE  Interaction: Q8NAC3; IntAct: EBI-21687716; Score: 0.35
DE  Interaction: Q9Y5H8; IntAct: EBI-21695064; Score: 0.35
DE  Interaction: Q9Y5G8; IntAct: EBI-21697051; Score: 0.35
DE  Interaction: P14778; IntAct: EBI-21700570; Score: 0.35
DE  Interaction: P08754; IntAct: EBI-21709056; Score: 0.35
DE  Interaction: Q86XK7; IntAct: EBI-21739948; Score: 0.35
DE  Interaction: Q8IV01; IntAct: EBI-21748151; Score: 0.35
DE  Interaction: Q6P9F7; IntAct: EBI-21762226; Score: 0.35
DE  Interaction: P40967; IntAct: EBI-21773380; Score: 0.35
DE  Interaction: Q99675; IntAct: EBI-21775037; Score: 0.35
DE  Interaction: Q5T2D2; IntAct: EBI-21777947; Score: 0.35
DE  Interaction: Q8NAU1; IntAct: EBI-21799562; Score: 0.35
DE  Interaction: A5X5Y0; IntAct: EBI-21800698; Score: 0.35
DE  Interaction: O43521; IntAct: EBI-21803818; Score: 0.35
DE  Interaction: Q9NRM6; IntAct: EBI-21807235; Score: 0.35
DE  Interaction: Q16445; IntAct: EBI-21828581; Score: 0.35
DE  Interaction: O76096; IntAct: EBI-21835330; Score: 0.35
DE  Interaction: Q8TEQ8; IntAct: EBI-21840858; Score: 0.35
DE  Interaction: Q9Y5E4; IntAct: EBI-21877083; Score: 0.35
DE  Interaction: Q9Y227; IntAct: EBI-21891924; Score: 0.35
DE  Interaction: P51957; IntAct: EBI-20721387; Score: 0.35
DE  Interaction: P22626; IntAct: EBI-20937172; Score: 0.40
DE  Interaction: P0DTC5; IntAct: EBI-25685699; Score: 0.53
DE  Interaction: P37173; IntAct: EBI-25892533; Score: 0.56
DE  Interaction: Q8NCK7; IntAct: EBI-27103180; Score: 0.35
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0031965;
GO  GO:0031090;
GO  GO:0031095;
GO  GO:0016529;
GO  GO:0033017;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0015085;
GO  GO:0030899;
GO  GO:0008656;
GO  GO:0046872;
GO  GO:0005388;
GO  GO:0015662;
GO  GO:0044325;
GO  GO:0006919;
GO  GO:0070588;
GO  GO:0006816;
GO  GO:1903515;
GO  GO:0006874;
GO  GO:0070059;
GO  GO:0034220;
GO  GO:1900121;
GO  GO:1903779;
GO  GO:0150104;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250};
SQ  MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEE
SQ  GEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVP
SQ  ADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA
SQ  AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLA
SQ  LGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQ
SQ  PVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMR
SQ  KEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLR
SQ  CLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG
SQ  IFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAM
SQ  GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTD
SQ  GLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDN
SQ  PLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVT
SQ  PLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK
//