ID  Q94218;
PN  Ufm1-specific protease;
GN  odr;
OS  6239;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23449979, ECO:0000269|PubMed:24603482}; Peripheral membrane protein {ECO:0000269|PubMed:24603482}. Cytoplasm {ECO:0000269|PubMed:24603482}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:23449979}. Note=Recruited to the endoplasmic reticulum upon interaction with odr-4. {ECO:0000269|PubMed:24603482}.
DR  UNIPROT: Q94218;
DR  UNIPROT: Q86MF8;
DR  PDB: 5EJJ;
DR  PDB: 5XDA;
DR  Pfam: PF07910;
DE  Function: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins (PubMed:29251776, PubMed:24603482). Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC (PubMed:9590179). Operates in aggregation behavior, and responses to oxygen levels (PubMed:12410303). {ECO:0000269|PubMed:12410303, ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:29251776, ECO:0000269|PubMed:9590179}.
DE  Reference Proteome: Yes;
GO  GO:0005789;
GO  GO:0048471;
GO  GO:0032991;
GO  GO:0071567;
GO  GO:0006935;
GO  GO:0050921;
GO  GO:0097499;
GO  GO:0006508;
GO  GO:0045471;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:24603482};
SQ  MTNSQTVSLIGPTQMAPQSTPPPPVNELWFIDAQAMFQNYANLRSFSKSNANEINTTIGGFVFGRKARKQVIHVLFAYAE
SQ  DLTESNRQFLESSLSADIELVGNLNIDGQSQILPGGQFTLQLTSRMLENRSISEFLDMNVMFNNEHVLMEGASCVSRVGY
SQ  EWSLRAGREQEDVKSAAERLSMASFRFTYLNAEHGLVIREQKPEAAQQKYLDKFSKGAVPYKDVIEFTAMQSLTRDTSND
SQ  TEDQKLVPTVKVTKDNKHFTRLVTIGEVVFPAFFGDSSLDLYKRSREAFNRRANNTMMVTVNGIRAGRGVTTTTSATYLP
SQ  PGWVSLLHLQLPTKWTDNEQRNYRIRLHKLFNLPSSKPVLRLSQALALHSESARLTNKKLIREPHLSITNYQPVGEITTV
SQ  NGPYNYHHYMQDGIDDSGWGCAYRSFQTIWSWFILNGYTDKPVPSHREIQQALVDIQDKQAKFVGSRQWIGSTEISFVLN
SQ  ELLKLECRFIATNSGAEVVERVRELARHFETSGTPVMIGGNMLAHTILGVDFNDTTGETKFLVLDPHYTGSEDIKTITSK
SQ  GWCAWKPASFWSKDHFYNMVLPQPPSDAI
//