ID  Q95017;
PN  SUMO-conjugating enzyme UBC9;
GN  ubc;
OS  6239;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus envelope {ECO:0000269|PubMed:25475837}.
DR  UNIPROT: Q95017;
DR  UNIPROT: Q9GYI5;
DR  Pfam: PF00179;
DR  PROSITE: PS00183;
DR  PROSITE: PS50127;
DE  Function: Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1, Polycomb protein sop-2, and intermediate filament proteins, such as ifb-1 (PubMed:15107848, PubMed:15689373, PubMed:24933177). Required for embryonic development, fertility, vulval morphogenesis, inhibition of vulval cell fates, lifespan, and neuromuscular activity (PubMed:24933177). {ECO:0000269|PubMed:11806825, ECO:0000269|PubMed:14711411, ECO:0000269|PubMed:15107848, ECO:0000269|PubMed:15689373, ECO:0000269|PubMed:15990876, ECO:0000269|PubMed:16701625, ECO:0000269|PubMed:24933177}.
DE  Reference Proteome: Yes;
DE  Interaction: Q95Q25; IntAct: EBI-344381; Score: 0.67
DE  Interaction: Q23158; IntAct: EBI-342641; Score: 0.00
DE  Interaction: Q95017; IntAct: EBI-367977; Score: 0.55
DE  Interaction: P55853; IntAct: EBI-367980; Score: 0.71
DE  Interaction: G5EF84; IntAct: EBI-2414823; Score: 0.49
DE  Interaction: Q9NA84; IntAct: EBI-2416847; Score: 0.49
DE  Interaction: Q21747; IntAct: EBI-2416839; Score: 0.49
DE  Interaction: Q94361; IntAct: EBI-2416843; Score: 0.49
DE  Interaction: Q21209; IntAct: EBI-3895794; Score: 0.51
DE  Interaction: P34342; IntAct: EBI-6463257; Score: 0.37
DE  Interaction: Q94420; IntAct: EBI-6883188; Score: 0.00
GO  GO:0005635;
GO  GO:0005634;
GO  GO:0005524;
GO  GO:0061629;
GO  GO:0032093;
GO  GO:0061656;
GO  GO:0009952;
GO  GO:0009792;
GO  GO:0000122;
GO  GO:0002119;
GO  GO:0043282;
GO  GO:0016925;
GO  GO:0032880;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSGIAAGRLAEERKHWRKDHPFGFIAKPVKNADGTLNLFNWECAIPGRKDTIWEGGLYRIRMLFKDDFPSTPPKCKFEPP
SQ  LFHPNVYPSGTVCLSLLDENKDWKPSISIKQLLIGIQDLLNHPNIEDPAQAEAYQIYCQNRAEYEKRVKKEAVKYAAELV
SQ  QKQMLE
//