ID  Q960X8;
PN  Hepatocyte growth factor-regulated tyrosine kinase substrate;
GN  Hrs;
OS  7227;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cell cortex {ECO:0000269|PubMed:11832215}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11832215}. Note=Locates to vesicles present in the perinuclear regions of muscle cells and in the periphery of Garland cells of third-instar larvae.
DR  UNIPROT: Q960X8;
DR  UNIPROT: A4V018;
DR  UNIPROT: Q8IGU6;
DR  UNIPROT: Q9VQF2;
DR  UNIPROT: Q9VQF3;
DR  PDB: 1DVP;
DR  Pfam: PF01363;
DR  Pfam: PF12210;
DR  Pfam: PF00790;
DR  PROSITE: PS50330;
DR  PROSITE: PS50179;
DR  PROSITE: PS50178;
DE  Function: Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. {ECO:0000269|PubMed:11832215}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8IQV9; IntAct: EBI-509966; Score: 0.37
DE  Interaction: P23573; IntAct: EBI-203520; Score: 0.00
DE  Interaction: Q9VNS1; IntAct: EBI-236619; Score: 0.00
DE  Interaction: O46339; IntAct: EBI-248743; Score: 0.00
DE  Interaction: Q9VLJ5; IntAct: EBI-253365; Score: 0.00
DE  Interaction: Q9W4P5; IntAct: EBI-259675; Score: 0.00
DE  Interaction: Q9VAD6; IntAct: EBI-259680; Score: 0.00
DE  Interaction: Q9V397; IntAct: EBI-259684; Score: 0.00
DE  Interaction: Q9XTL2; IntAct: EBI-259688; Score: 0.00
DE  Interaction: O46036; IntAct: EBI-259692; Score: 0.00
DE  Interaction: P68198; IntAct: EBI-300719; Score: 0.40
DE  Interaction: Q9VVT5; IntAct: EBI-509756; Score: 0.37
DE  Interaction: Q9Y103; IntAct: EBI-509763; Score: 0.00
DE  Interaction: P18091; IntAct: EBI-509770; Score: 0.00
DE  Interaction: Q8SXD4; IntAct: EBI-509777; Score: 0.00
DE  Interaction: Q7KLE5; IntAct: EBI-509784; Score: 0.00
DE  Interaction: Q9V595; IntAct: EBI-509791; Score: 0.37
DE  Interaction: Q03017; IntAct: EBI-509798; Score: 0.37
DE  Interaction: Q9VH60; IntAct: EBI-509805; Score: 0.37
DE  Interaction: Q95RP4; IntAct: EBI-509812; Score: 0.37
DE  Interaction: Q9VCB8; IntAct: EBI-509819; Score: 0.37
DE  Interaction: Q23983; IntAct: EBI-509826; Score: 0.37
DE  Interaction: Q9VEN1; IntAct: EBI-509833; Score: 0.00
DE  Interaction: Q00963; IntAct: EBI-509840; Score: 0.37
DE  Interaction: A1Z9J3; IntAct: EBI-509847; Score: 0.37
DE  Interaction: Q9VN68; IntAct: EBI-509854; Score: 0.00
DE  Interaction: Q9VXG4; IntAct: EBI-509861; Score: 0.37
DE  Interaction: Q7YU91; IntAct: EBI-509868; Score: 0.37
DE  Interaction: Q8SXA8; IntAct: EBI-509875; Score: 0.00
DE  Interaction: Q9VW47; IntAct: EBI-509882; Score: 0.37
DE  Interaction: P29742; IntAct: EBI-509896; Score: 0.37
DE  Interaction: Q9VC36; IntAct: EBI-509903; Score: 0.37
DE  Interaction: O44381; IntAct: EBI-509917; Score: 0.37
DE  Interaction: Q9VPL5; IntAct: EBI-509924; Score: 0.37
DE  Interaction: P54360; IntAct: EBI-509931; Score: 0.37
DE  Interaction: P48608; IntAct: EBI-509938; Score: 0.00
DE  Interaction: P07666; IntAct: EBI-509945; Score: 0.37
DE  Interaction: Q8T987; IntAct: EBI-509952; Score: 0.37
DE  Interaction: Q7KN74; IntAct: EBI-509959; Score: 0.37
DE  Interaction: O02373; IntAct: EBI-509973; Score: 0.37
DE  Interaction: Q9VM75; IntAct: EBI-509980; Score: 0.37
DE  Interaction: P08953; IntAct: EBI-15848965; Score: 0.35
DE  Interaction: Q9VUH6; IntAct: EBI-15848965; Score: 0.35
GO  GO:0005938;
GO  GO:0005829;
GO  GO:0005769;
GO  GO:0005768;
GO  GO:0048471;
GO  GO:0046872;
GO  GO:0035091;
GO  GO:0043130;
GO  GO:0045022;
GO  GO:0032456;
GO  GO:0006897;
GO  GO:0016197;
GO  GO:0032509;
GO  GO:1990182;
GO  GO:0045879;
GO  GO:0120177;
GO  GO:0016322;
GO  GO:1903688;
GO  GO:0045752;
GO  GO:0061357;
GO  GO:0031623;
GO  GO:0051726;
GO  GO:2000274;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MFRSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEE
SQ  VFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWAD
SQ  GRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPA
SQ  EYLNSTLAQQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEAT
SQ  NPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRG
SQ  RSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQM
SQ  AQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAA
SQ  GVPGYLPQGPAPAPNGHGQFQAIPPGMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQH
SQ  SIAQPPQIPFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPVQQPQPQPQMGHVMLQQHQAPPAAQAPPVT
SQ  EIANNQVQAVAAAPAPPQNEPGPAPVKAEEPATAELISFD
//